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Creating the bioartificial myocardium for cardiac repair: challenges and clinical targets

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Creating the bioartificial myocardium for cardiac repair: challenges and clinical targets

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dc.contributor.author Chachques, Juan C. es_ES
dc.contributor.author Monleón Pradas, Manuel es_ES
dc.contributor.author Bayes-Genis, Antoni es_ES
dc.contributor.author Semino, Carlos es_ES
dc.date.accessioned 2018-04-21T04:16:18Z
dc.date.available 2018-04-21T04:16:18Z
dc.date.issued 2013 es_ES
dc.identifier.issn 1477-9072 es_ES
dc.identifier.uri http://hdl.handle.net/10251/100791
dc.description.abstract [EN] The association of stem cells with tissue-engineered scaffolds constitutes an attractive approach for the repair of myocardial tissue with positive effects to avoid ventricular chamber dilatation, which changes from a natural elliptical to spherical shape in heart failure patients. Biohybrid scaffolds using nanomaterials combined with stem cells emerge as new therapeutic tool for the creation of `bioartificial myocardium¿ and `cardiac wrap bioprostheses¿ for myocardial regeneration and ventricular support. Biohybrids are created introducing stem cells and self-assembling peptide nanofibers inside a porous elastomeric membrane, forming cell niches. Our studies lead to the creation of semi-degradable `ventricular support bioprostheses¿ for adaptative LV and/or RV wrapping, designed with the concept of `helical myocardial bands¿. The goal is to restore LV elliptical shape, and contribute to systolic contraction and diastolic filling (suction mechanism). Cardiac wrapping with ventricular bioprostheses may reduce the risk of heart failure progression and the indication for heart transplantation. es_ES
dc.description.sponsorship The RECATABI PROJECT (Regeneration of Cardiac Tissue Assisted by Bioactive Implants) was financially supported by the 7th Framework Programme (FP7) of the European Commission. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.
dc.language Inglés es_ES
dc.publisher Taylor & Francis es_ES
dc.relation.ispartof Expert Review of Cardiovascular Therapy es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Bioartificial myocardium es_ES
dc.subject Biohybrid scaffolds es_ES
dc.subject Bionanomaterials es_ES
dc.subject Cardiac bioregeneration es_ES
dc.subject Cardiomyoplasty es_ES
dc.subject Cell transplantation es_ES
dc.subject Heart failure es_ES
dc.subject Myocardial infarction es_ES
dc.subject Myocardial regeneration es_ES
dc.subject Tissue engineering es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Creating the bioartificial myocardium for cardiac repair: challenges and clinical targets es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1586/14779072.2013.854165 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/229239/EU
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Chachques, JC.; Monleón Pradas, M.; Bayes-Genis, A.; Semino, C. (2013). Creating the bioartificial myocardium for cardiac repair: challenges and clinical targets. Expert Review of Cardiovascular Therapy. 11(12):1701-1711. https://doi.org/10.1586/14779072.2013.854165 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1586/14779072.2013.854165 es_ES
dc.description.upvformatpinicio 1701 es_ES
dc.description.upvformatpfin 1711 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 11 es_ES
dc.description.issue 12 es_ES
dc.relation.pasarela S\263001 es_ES
dc.contributor.funder European Commission es_ES


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