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dc.contributor.author | Castellví, Quim![]() |
es_ES |
dc.contributor.author | Sánchez Velazquez, Patricia![]() |
es_ES |
dc.contributor.author | Moll, Xavier![]() |
es_ES |
dc.contributor.author | Berjano, Enrique![]() |
es_ES |
dc.contributor.author | Andaluz, Anna![]() |
es_ES |
dc.contributor.author | Burdío, Fernando![]() |
es_ES |
dc.contributor.author | Bijnens, Bart![]() |
es_ES |
dc.contributor.author | Ivorra, Antoni![]() |
es_ES |
dc.date.accessioned | 2018-05-18T04:18:20Z | |
dc.date.available | 2018-05-18T04:18:20Z | |
dc.date.issued | 2018 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/102163 | |
dc.description.abstract | [EN] Metastases in the liver frequently grow as scattered tumor nodules that neither can be removed by surgical resection nor focally ablated. Previously, we have proposed a novel technique based on irreversible electroporation that may be able to simultaneously treat all nodules in the liver while sparing healthy tissue. The proposed technique requires increasing the electrical conductivity of healthy liver by injecting a hypersaline solution through the portal vein. Aiming to assess the capability of increasing the global conductivity of the liver by means of hypersaline fluids, here, it is presented a mathematical model that estimates the NaCl distribution within the liver and the resulting conductivity change. The model fuses well-established compartmental pharmacokinetic models of the organ with saline injection models used for resuscitation treatments, and it considers changes in sinusoidal blood viscosity because of the hypertonicity of the solution. Here, it is also described a pilot experimental study in pigs in which different volumes of NaCl 20% (from 100 to 200mL) were injected through the portal vein at different flow rates (from 53 to 171 mL/minute). The in vivo conductivity results fit those obtained by the model, both quantitatively and qualitatively, being able to predict the maximum conductivity with a 14.6% average relative error. The maximum conductivity value was 0.44second/m, which corresponds to increasing 4 times the mean basal conductivity (0.11second/m). The results suggest that the presented model is well suited for predicting on liver conductivity changes during hypertonic saline injection. | es_ES |
dc.description.sponsorship | Ministry of Economy and Competitiveness of Spain, Grant/Award Number: TEC2014-52383-C3-1-R, TEC2014-52383-C3-2-R, TEC2014-52383-C3-3-R | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | John Wiley & Sons | es_ES |
dc.relation.ispartof | International Journal for Numerical Methods in Biomedical Engineering | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Bioimpedance | es_ES |
dc.subject | Electroporation | es_ES |
dc.subject | Hypertonic solutions | es_ES |
dc.subject | Liver | es_ES |
dc.subject | Numerical modelling of organs | es_ES |
dc.subject.classification | TECNOLOGIA ELECTRONICA | es_ES |
dc.title | Modeling Liver Electrical Conductivity during Hypertonic Injection | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1002/cnm.2904 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//TEC2014-52383-C3-1-R/ES/TECNOLOGIAS BASADAS EN ENERGIA DE RADIOFRECUENCIA Y MICROONDAS PARA CIRUGIA DE MINIMA INVASION/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.date.embargoEndDate | 2018-01-01 | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica | es_ES |
dc.description.bibliographicCitation | Castellví, Q.; Sánchez Velazquez, P.; Moll, X.; Berjano, E.; Andaluz, A.; Burdío, F.; Bijnens, B.... (2018). Modeling Liver Electrical Conductivity during Hypertonic Injection. International Journal for Numerical Methods in Biomedical Engineering. 34(1):2904-2918. doi:10.1002/cnm.2904 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1002/cnm.2904 | es_ES |
dc.description.upvformatpinicio | 2904 | es_ES |
dc.description.upvformatpfin | 2918 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 34 | es_ES |
dc.description.issue | 1 | es_ES |
dc.identifier.eissn | 2040-7947 | es_ES |
dc.relation.pasarela | S\337548 | es_ES |
dc.contributor.funder | Ministerio de Economía, Industria y Competitividad | es_ES |