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Influence of the Hydrophobic-Hydrophilic Nature of Biomedical Polymers and Nanocomposites on In Vitro Biological Development

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Influence of the Hydrophobic-Hydrophilic Nature of Biomedical Polymers and Nanocomposites on In Vitro Biological Development

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dc.contributor.author Torres-Roca, Elena es_ES
dc.contributor.author Vallés Lluch, Ana es_ES
dc.contributor.author Fombuena, Vicent es_ES
dc.contributor.author Napiwocki, Brett es_ES
dc.contributor.author Lih-Sheng, Turng es_ES
dc.date.accessioned 2018-05-25T04:18:58Z
dc.date.available 2018-05-25T04:18:58Z
dc.date.issued 2017 es_ES
dc.identifier.issn 1438-7492 es_ES
dc.identifier.uri http://hdl.handle.net/10251/102605
dc.description.abstract [EN] In this work, cell viability, proliferation, and morphology are studied on two pairs of polymers used in the biomedical field that have similar chemical natures but differ in hydrophobicity. On the one hand, hydrophobic polyester poly(epsilon-caprolactone), is modified by blending with poly(lactic acid). On the other hand, the hydrophilic acrylate poly(2-hydroxyethyl methacrylate) (PHEMA), is copolymerized with ethyl methacrylate (EMA) at a ratio of 50/50 wt.% P(HEMA-co-EMA). These two polymers are used as neat resins or combined with hydroxyapatite (HA) nanoparticles and halloysite nanotubes (HNTs) to enhance cell attachment and mechanical properties. Cell proliferation is greater on moderately hydrophobic materials at the initial stage, with cells showing a round shape and aggregating in clusters. However, over longer culture periods, cell proliferation is more advanced on more hydrophilic surfaces, where cells spread out with a flatter shape. Improvement of cell viability is observed with the addition of HA and HNTs. es_ES
dc.description.sponsorship A.V.-L. acknowledges Spanish Ministry of Economy and Competitiveness through DPI2015-65401-C3-2-R project. es_ES
dc.description.sponsorship A.V.-L. acknowledges Spanish Ministry of Economy and Competitiveness through DPI2015-65401- C3-2-R project.
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation MINISTERIO DE ECONOMIA INDUSTRIA Y COMPETITIVIDAD /DPI2015-65401-C3-2-R es_ES
dc.relation.ispartof Macromolecular Materials and Engineering es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Biocompatibility es_ES
dc.subject Blends es_ES
dc.subject Functionalization of polymers es_ES
dc.subject Hydrophilic polymers es_ES
dc.subject Nanocomposites es_ES
dc.subject.classification CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA es_ES
dc.subject.classification INGENIERIA QUIMICA es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Influence of the Hydrophobic-Hydrophilic Nature of Biomedical Polymers and Nanocomposites on In Vitro Biological Development es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/mame.201700259 es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Química y Nuclear - Departament d'Enginyeria Química i Nuclear es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Torres-Roca, E.; Vallés Lluch, A.; Fombuena, V.; Napiwocki, B.; Lih-Sheng, T. (2017). Influence of the Hydrophobic-Hydrophilic Nature of Biomedical Polymers and Nanocomposites on In Vitro Biological Development. Macromolecular Materials and Engineering. 302(12). doi:10.1002/mame.201700259 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1002/mame.201700259 es_ES
dc.description.upvformatpinicio 1700259 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 302 es_ES
dc.description.issue 12 es_ES
dc.relation.pasarela S\353087 es_ES
dc.contributor.funder Ministerio de Economía, Industria y Competitividad es_ES


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