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Improvement of mechanical and biological properties of Polycaprolactone loaded with Hydroxyapatite and Halloysite Nanotubes

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Improvement of mechanical and biological properties of Polycaprolactone loaded with Hydroxyapatite and Halloysite Nanotubes

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dc.contributor.author Torres-Roca, Elena es_ES
dc.contributor.author Fombuena, Vicent es_ES
dc.contributor.author Vallés Lluch, Ana es_ES
dc.contributor.author Ellingham, T. es_ES
dc.date.accessioned 2018-05-26T04:22:30Z
dc.date.available 2018-05-26T04:22:30Z
dc.date.issued 2017 es_ES
dc.identifier.issn 0928-4931 es_ES
dc.identifier.uri http://hdl.handle.net/10251/102696
dc.description.abstract [EN] Hydroxyapatite (HA) and Halloysite nanotubes (HNTs) percentages have been optimized in Polycaprolactone (PCL) polymeric matrices to improve mechanical, thermal and biological properties of the composites, thus, to be applied in bone tissue engineering or as fixation plates. Addition of HA guarantees a proper compatibility with human bone due to its osteoconductive and osteoinductive properties, facilitating bone regeneration in tissue engineering applications. Addition of HNTs ensures the presence of tubular structures for subsequent drug loading in their lumen, of molecules such as curcumin, acting as controlled drug delivery systems. The addition of 20% of HA and different amounts of HNTs leads to a substantial improvement in mechanical properties with values of flexural strength up to 40% over raw PCL, with an increase in degradation temperature. DMA analyses showed stability in mechanical and thermal properties, having as a result a potential composite to be used as tissue engineering scaffold or resorbable fixation plate. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Materials Science and Engineering C es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Polycaprolactone es_ES
dc.subject Hydroxyapatite es_ES
dc.subject Halloysite es_ES
dc.subject Curcumin es_ES
dc.subject Tissue engineering es_ES
dc.subject.classification CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA es_ES
dc.subject.classification INGENIERIA QUIMICA es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Improvement of mechanical and biological properties of Polycaprolactone loaded with Hydroxyapatite and Halloysite Nanotubes es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.msec.2017.02.087 es_ES
dc.rights.accessRights Abierto es_ES
dc.date.embargoEndDate 2019-06-01 es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Química y Nuclear - Departament d'Enginyeria Química i Nuclear es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Torres-Roca, E.; Fombuena, V.; Vallés Lluch, A.; Ellingham, T. (2017). Improvement of mechanical and biological properties of Polycaprolactone loaded with Hydroxyapatite and Halloysite Nanotubes. Materials Science and Engineering C. 75:418-424. doi:10.1016/j.msec.2017.02.087 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1016/j.msec.2017.02.087 es_ES
dc.description.upvformatpinicio 418 es_ES
dc.description.upvformatpfin 424 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 75 es_ES
dc.identifier.pmid 28415480
dc.relation.pasarela S\328228 es_ES


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