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EFFECTS OF PROSTAGLANDIN F2a AND ITS ANALOGS ON PLASMA ESTRADIOL 17-B AND PROGESTERONE LEVELS IN DOE RABBITS

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EFFECTS OF PROSTAGLANDIN F2a AND ITS ANALOGS ON PLASMA ESTRADIOL 17-B AND PROGESTERONE LEVELS IN DOE RABBITS

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dc.contributor.author Negatu, Z.
dc.contributor.author McNitt, J.I.
dc.contributor.author Simon, G.
dc.contributor.author Mellad, K.E.
dc.date.accessioned 2011-03-14T12:15:58Z
dc.date.available 2011-03-14T12:15:58Z
dc.date.issued 1998
dc.identifier.issn 1257-5011
dc.identifier.uri http://hdl.handle.net/10251/10324
dc.description.abstract [EN] To assess the effect of prostaglandin Fa:,and two of its analogs on plasma estradiol-17p and progesterone levels in the immediate post partum period, 19 primiparous New Zealand White does were injected on day 29 of pregnancy with prostaglandin F21x (Lutalyse: ®Upjohn; 4 does), cloprostenol (Estrumate: ®Mobay Corp.; 5 does), fenprostalene (Bovilene: ®Syntex Animal Health; 4 does), or sterile saline as a control (6 does). Treatment with prostaglandin F21x and the two analogs shortened the gestation period by more than one day when compared to the saline treated group (p<0.05) but there were no effects of treatment on the number of kits bom, number of kits bom alive or the mean birth weight of the kits. Treatment with prostaglandin F21x and analogs lowered the plasma estradiol-17p and progesterone levels immediately following treatment. After kindling, the prostaglandin-treated does had a dramatic increase in plasma estradiol peaking at three days and retuming to post-treatment levels about day five. The treated does had low plasma progesterone levels with minor fluctuations until about six days post-partum when a slow rise began. lt is speculated that the elevated estradiol and lowered progesterone levels could might have beneficia! effects on prolactin related activities in the immediate post-partum period. es_ES
dc.description.abstract [FR] Dix-neuf lapines néo-zélandaises primipares ont été utilisées pour évaluer l'effet de la prostaglandine F2a et de deux de ses analogues pendant la période immédiatement post-partum. La prostaglandine F2a (Lutalyse : ®Upjohn, 4 lapines), le cloprostenol (Estrumate : ®Mobay Corp., 5 lapines) le fenprostaléne (Bovilene : ®Syntex Animal Health, 4 lapines) et une solution saline stérile (lot controle, 6 lapines) ont été injectés a ces lapines, au 29ém• jour de gestation. Le traitement par la prostaglandine F2a et ses 2 analogues comparés a la solution saline, raccourcit la durée de la gestation de plus d'un jour (P<0,05) mais n'a pas de conséquences sur le nombre total de lapereaux nés, le nombre de lapereaux nés vivants ou le poids moyen des lapereaux a la naissance. La prostaglandine F2a et ses 2 analogues diminuent, immédiatement aprés le traitement, les taux d'oestradiol 17-p et de progestérone sanguins. Au troisiéme jour aprés la mise bas, on observe un pie importan! du taux d'oestradiol chez les lapines traitées par la prostaglandine, qui revient le cinquiéme jour au niveau précédent le traitement. Les lapines traitées ont un taux de progestérone faible avec de petites fluctuations jusqu'a environ de sixiéme jour post-partum, puis une légére augmentation s'amorce. On peut supposer que les taux, élevé d'oestradiol et faible de progestérone, ont un effet bénéfique sur l'activité de la prolactine pendant la période post-partum.
dc.language Inglés es_ES
dc.publisher World Rabbit Science. ICTA. UPV es_ES
dc.relation.ispartof World Rabbit Science
dc.rights Reserva de todos los derechos es_ES
dc.title EFFECTS OF PROSTAGLANDIN F2a AND ITS ANALOGS ON PLASMA ESTRADIOL 17-B AND PROGESTERONE LEVELS IN DOE RABBITS es_ES
dc.type Artículo es_ES
dc.date.updated 2011-03-14T11:50:07Z
dc.identifier.doi 10.4995/wrs.1998.364
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Negatu, Z.; Mcnitt, J.; Simon, G.; Mellad, K. (1998). EFFECTS OF PROSTAGLANDIN F2a AND ITS ANALOGS ON PLASMA ESTRADIOL 17-B AND PROGESTERONE LEVELS IN DOE RABBITS. World Rabbit Science. 6(3-4). doi:10.4995/wrs.1998.364 es_ES
dc.description.accrualMethod SWORD es_ES
dc.relation.publisherversion https://doi.org/10.4995/wrs.1998.364
dc.description.volume 6
dc.description.issue 3-4
dc.identifier.eissn 1989-8886 es_ES


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