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Intra-ocular lens optical changes resulting from the loading of dexamethasone

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Intra-ocular lens optical changes resulting from the loading of dexamethasone

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dc.contributor.author Artigas, Jose M. es_ES
dc.contributor.author Garcia-Domene, M. Carmen es_ES
dc.contributor.author Navea, Amparo es_ES
dc.contributor.author Botella Asuncion, Pablo es_ES
dc.contributor.author Fernandez, Eduardo es_ES
dc.date.accessioned 2018-06-08T04:20:44Z
dc.date.available 2018-06-08T04:20:44Z
dc.date.issued 2017 es_ES
dc.identifier.uri http://hdl.handle.net/10251/103603
dc.description.abstract [EN] To study the optical changes on hydrogel-silicone intraocular lenses (IOLs) resulting from loading them with dexamethasone. We used prototype hydrogel(pHEMA)silicone IOLs and loaded the matrices with an anti-inflammatory drug (dexamethasone). The optical properties we analyzed experimentally were a) modulation transfer function (MTF); b) spectral transmission; c) diopter power. These determinations were performed on drug-loaded IOLs, IOLs that had released the drug, and IOLs that had not been drug-loaded. Loading a hydrogel-silicone IOL with dexamethasone results in impairment of its optical qualities, in particular its MTF and spectral transmission, but not dioptric power. However, once the drug has been released, it almost recovers its initial optical properties. es_ES
dc.description.sponsorship Project IPT-2012-0574-300000 (Spain) and AJL Ophthalmic S.A. (Vitoria, Spain). es_ES
dc.language Inglés es_ES
dc.publisher Optical Society of America es_ES
dc.relation.ispartof Biomedical Optics Express es_ES
dc.rights Reconocimiento (by) es_ES
dc.title Intra-ocular lens optical changes resulting from the loading of dexamethasone es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1364/BOE.8.004621 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//IPT-2012-0574-300000/ES/Desarrollo de una nueva generación de lentes intraoculares multifuncionales(HORUS)/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química es_ES
dc.description.bibliographicCitation Artigas, JM.; Garcia-Domene, MC.; Navea, A.; Botella Asuncion, P.; Fernandez, E. (2017). Intra-ocular lens optical changes resulting from the loading of dexamethasone. Biomedical Optics Express. 8(10):4621-4628. https://doi.org/10.1364/BOE.8.004621 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1364/BOE.8.004621 es_ES
dc.description.upvformatpinicio 4621 es_ES
dc.description.upvformatpfin 4628 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 8 es_ES
dc.description.issue 10 es_ES
dc.identifier.eissn 2156-7085 es_ES
dc.relation.pasarela S\358642 es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder European Regional Development Fund
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