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Correlating synthesis parameters with physicochemical properties of poly(glycerol sebacate)

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Correlating synthesis parameters with physicochemical properties of poly(glycerol sebacate)

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dc.contributor.author Conejero-Garcia, Álvaro es_ES
dc.contributor.author Rivero-Gimeno, H. es_ES
dc.contributor.author Moreno-Sáez, Y. es_ES
dc.contributor.author Vilarino-Feltrer, G es_ES
dc.contributor.author Ortuño-Lizarán, Isabel es_ES
dc.contributor.author Vallés Lluch, Ana es_ES
dc.date.accessioned 2018-06-11T04:26:44Z
dc.date.available 2018-06-11T04:26:44Z
dc.date.issued 2017 es_ES
dc.identifier.issn 0014-3057 es_ES
dc.identifier.uri http://hdl.handle.net/10251/103778
dc.description.abstract [EN] Poly(glycerol sebacate), PGS, is an elastomeric biodegradable polyester increasingly proposed in a variety of biomedical applications. It is prepared by polycondensation of sebacic acid and glycerol in a first stage in which a prepolymer is obtained, followed by a curing to conveniently crosslink it. In this work, synthesis parameters such as the curing temperature and time, and the molar ratio between reactants, were systematically varied to correlate them with the physicochemical properties of the resulting polymer networks. The efficiency of each manufacturing process was quantified through, the relative mass effectively crosslinked and insoluble in tetrahydrofuran. Infrared spectra gave an estimation of the ratio of non-condensed polar terminal groups. These results were correlated with swelling results, which in turn provided the means to calculate the chains density through Flory-Rehner equilibrium swelling equation for lightly crosslinked polymers. The role of the synthesis parameters on the physical state of the resulting polymers, as well as their proneness to hydrolyze, were followed. The results obtained highlight the relevance of rinsing them following synthesis, to remove non-crosslinked chains that easily diffuse to the surrounding medium. Curing under mild conditions equimolar mixtures of sebacic acid and glycerol proved to lead to poorly crosslinked swellable networks, which hydrolyze easily in bulk mode. Alternative molar ratios yield sticky and difficult to handle materials at higher polyol fractions in the reactive mixture, whilst an excess of acid terminal groups leads to a faster mass loss by hydrolysis in aqueous media together with surface salts deposition, concomitant with a lesser cell viability in in vitro culture. PGS synthesized from an equimolar ratio between reactants and cured at 130 degrees C or higher, for 48 h or longer, show suitable features for their use in tissue engineering applications where hydrophobic surface-degradable rubbers are required, without significant differences among them. es_ES
dc.description.sponsorship The authors acknowledge Spanish Ministerio de Economia y Competitividad through DPI2015-65401-C3-2-R project. en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation MINISTERIO DE ECONOMIA INDUSTRIA Y COMPETITIVIDAD /DPI2015-65401-C3-2-R es_ES
dc.relation.ispartof European Polymer Journal es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Poly(glycerol sebacate) es_ES
dc.subject Biodegradable es_ES
dc.subject Elastomer es_ES
dc.subject Condensation es_ES
dc.subject Curing es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Correlating synthesis parameters with physicochemical properties of poly(glycerol sebacate) es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.eurpolymj.2017.01.001 es_ES
dc.rights.accessRights Abierto es_ES
dc.date.embargoEndDate 2019-02-01 es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Conejero-Garcia, Á.; Rivero-Gimeno, H.; Moreno-Sáez, Y.; Vilarino-Feltrer, G.; Ortuño-Lizarán, I.; Vallés Lluch, A. (2017). Correlating synthesis parameters with physicochemical properties of poly(glycerol sebacate). European Polymer Journal. 87:406-419. doi:10.1016/j.eurpolymj.2017.01.001 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.eurpolymj.2017.01.001 es_ES
dc.description.upvformatpinicio 406 es_ES
dc.description.upvformatpfin 419 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 87 es_ES
dc.relation.pasarela 325386 es_ES
dc.contributor.funder MINISTERIO DE ECONOMIA INDUSTRIA Y COMPETITIVIDAD es_ES


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