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Diminishing returns of inoculum size on the rate of a plant RNA virus evolution

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Diminishing returns of inoculum size on the rate of a plant RNA virus evolution

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dc.contributor.author Navarro, Rebeca es_ES
dc.contributor.author Ambros Palaguerri, Silvia es_ES
dc.contributor.author Martinez, Fernando es_ES
dc.contributor.author Elena Fito, Santiago Fco. es_ES
dc.date.accessioned 2018-06-28T04:24:35Z
dc.date.available 2018-06-28T04:24:35Z
dc.date.issued 2017 es_ES
dc.identifier.issn 0295-5075 es_ES
dc.identifier.uri http://hdl.handle.net/10251/104727
dc.description.abstract [EN] Understanding how genetic drift, mutation and selection interplay in determining the evolutionary fate of populations is one of the central themes of Evolutionary Biology. Theory predicts that by increasing the number of coexisting beneficial alleles in a population beyond some point does not necessarily translates into an acceleration in the rate of evolution. This diminishing-returns effect of beneficial genetic variability in microbial asexual populations is known as clonal interference. Clonal interference has been shown to operate in experimental populations of animal RNA viruses replicating in cell cultures. Here we carried out experiments to test whether a similar diminishing-returns of population size on the rate of adaptation exists for a plant RNA virus infecting real multicellular hosts. We have performed evolution experiments with tobacco etch potyvirus in two hosts, the natural and a novel one, at different inoculation sizes and estimated the rates of evolution for two phenotypic fitness-related traits. Firstly, we found that evolution proceeds faster in the novel than in the original host. Secondly, results were compatible with a diminishing-returns effect of inoculum size on the rate of evolution for one of the fitness traits, but not for the other, which suggests that selection operates differently on each trait. es_ES
dc.description.sponsorship We thank F. DE LA IGLESIA and P. AGUDO for excellent technical support and J. A. CUESTA for critical reading and insightful suggestions. This work was supported by grant BFU2015-65037-P from Spain's Ministry of Economy, Industry and Competitiveness and by the Santa Fe Institute. en_EN
dc.language Inglés es_ES
dc.publisher IOP Publishing - Europhysics Letters es_ES
dc.relation Ministerio de Economía, Industria y Competitividad/BFU2015-65037-P es_ES
dc.relation.ispartof EPL (Europhysics Letters) es_ES
dc.rights Reserva de todos los derechos es_ES
dc.title Diminishing returns of inoculum size on the rate of a plant RNA virus evolution es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1209/0295-5075/120/38001 es_ES
dc.rights.accessRights Abierto es_ES
dc.date.embargoEndDate 2018-12-01 es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation Navarro, R.; Ambros Palaguerri, S.; Martinez, F.; Elena Fito, SF. (2017). Diminishing returns of inoculum size on the rate of a plant RNA virus evolution. EPL (Europhysics Letters). 120(38001):1-6. doi:10.1209/0295-5075/120/38001 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1209/0295-5075/120/38001 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 6 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 120 es_ES
dc.description.issue 38001 es_ES
dc.relation.pasarela S\357618 es_ES
dc.contributor.funder Ministerio de Economía, Industria y Competitividad es_ES


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