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The expression of nuclear and membrane estrogen receptors in the European eel throughout spermatogenesis

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The expression of nuclear and membrane estrogen receptors in the European eel throughout spermatogenesis

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dc.contributor.author MORINI, MARINA es_ES
dc.contributor.author Peñaranda, D.S. es_ES
dc.contributor.author Vilchez Olivencia, Maria Carmen es_ES
dc.contributor.author Tveiten, Helge es_ES
dc.contributor.author Lafont, Anne-Gaëlle es_ES
dc.contributor.author Dufour, Sylvie es_ES
dc.contributor.author Pérez Igualada, Luz María es_ES
dc.contributor.author Asturiano Nemesio, Juan Francisco es_ES
dc.date.accessioned 2018-06-28T04:27:17Z
dc.date.available 2018-06-28T04:27:17Z
dc.date.issued 2017 es_ES
dc.identifier.issn 1095-6433 es_ES
dc.identifier.uri http://hdl.handle.net/10251/104734
dc.description.abstract [EN] Estradiol (E-2) can bind to nuclear estrogen receptors (ESR) or membrane estrogen receptors (GPER). While mammals possess two nuclear ESRs and one membrane GPER, the European eel, like most other teleosts, has three nuclear ESRs and two membrane GPERs, as the result of a teleost specific genome duplication. In the current study, the expression of the three nuclear ESRs (ESR1, ESR2a and ESR2b) and the two membrane GPERs (GPERa and GPERb) in the brain-pituitary-gonad (BPG) axis of the European eel was measured, throughout spermatogenesis. The eels were first transferred from freshwater (FW) to seawater (SW), inducing parallel increases in E2 plasma levels and the expression of ESRs. This indicates that salinity has a stimulatory effect on the E-2 signalling pathway along the BPG axis. Stimulation of sexual maturation by weekly injections of human chorionic gonadotropin (hCG) induced a progressive decrease in E-2 plasma levels, and different patterns of expression of ESRs and GPERs in the BPG axis. The expression of nuclear ESRs increased in some parts of the brain, suggesting a possible upregulation due to a local production of E-2. In the testis, the highest expression levels of the nuclear ESRs were observed at the beginning of spermatogenesis, possibly mediating the role of E2 as spermatogonia renewal factor, followed by a sharply decrease in the expression of ESRs. Conversely, there was a marked increase observed in the expression of both membrane GPERs throughout spermatogenesis, suggesting they play a major role in the final stages of spermatogenesis. es_ES
dc.description.sponsorship Funded by the Spanish Ministry of Science and Innovation (REPRO-TEMP project; AGL2013-41646-R) and IMPRESS (Marie Sklodowska-Curie Actions; Grant agreement no: 642893). M.C. Vilchez has a predoctoral grant from UPV PAID Programme (2011-S2-02-6521), M. Morini has a predoctoral grant from Generalitat Valenciana (Programa Grisolia). D.S. Penaranda was supported by MICINN and UPV (PTA2011-4948-1). en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation info:eu-repo/grantAgreement/MINECO//AGL2013-41646-R/ES/LA ANGUILA EUROPEA COMO MODELO PARA ESTUDIAR LA TEMPERATURA COMO MODULADOR DE LA MADURACION SEXUAL EN TELEOSTEOS. POTENCIAL APLICACION EN ACUICULTURA./ es_ES
dc.relation MINISTERIO DE ECONOMIA INDUSTRIA Y COMPETITIVIDAD /PTA2011-4948-I es_ES
dc.relation COMISION DE LAS COMUNIDADES EUROPEA/642893//MSCA-ITN-2014-ETN es_ES
dc.relation.ispartof Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject ESR es_ES
dc.subject GPER es_ES
dc.subject Anguilla es_ES
dc.subject Teleost es_ES
dc.subject Reproduction es_ES
dc.subject.classification BIOLOGIA ANIMAL es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.title The expression of nuclear and membrane estrogen receptors in the European eel throughout spermatogenesis es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.cbpa.2016.08.020 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Ciencia y Tecnología Animal - Institut de Ciència i Tecnologia Animal es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.description.bibliographicCitation Morini, M.; Peñaranda, D.; Vilchez Olivencia, MC.; Tveiten, H.; Lafont, A.; Dufour, S.; Pérez Igualada, LM.... (2017). The expression of nuclear and membrane estrogen receptors in the European eel throughout spermatogenesis. Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology. 203:91-99. doi:10.1016/j.cbpa.2016.08.020 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.cbpa.2016.08.020 es_ES
dc.description.upvformatpinicio 91 es_ES
dc.description.upvformatpfin 99 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 203 es_ES
dc.relation.pasarela S\316369 es_ES
dc.contributor.funder European Commission es_ES
dc.contributor.funder Ministerio de Economía, Industria y Competitividad es_ES


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