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Surface-modified silica nanoparticles for tumor-targeted delivery of camptothecin and its biological evaluation

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Surface-modified silica nanoparticles for tumor-targeted delivery of camptothecin and its biological evaluation

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Botella Asuncion, P.; Abasolo, I.; Fernández, Y.; Muniesa Lajara, C.; Miranda, S.; Quesada Vilar, M.; Ruiz Carrascal, J.... (2011). Surface-modified silica nanoparticles for tumor-targeted delivery of camptothecin and its biological evaluation. Journal of Controlled Release. 156(2):246-257. doi:10.1016/j.jconrel.2011.06.039

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Title: Surface-modified silica nanoparticles for tumor-targeted delivery of camptothecin and its biological evaluation
Author:
UPV Unit: Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
Universitat Politècnica de València. Departamento de Química - Departament de Química
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Abstract:
[EN] Here we report the design, synthesis and biological evaluation of surface-modified silica nanoparticles (SNP) for the delivery of camptothecin (CPT). Drug has been covalently linked to the nanoparticle through an ester ...[+]
Subjects: Silica-nanoparticles , Camptothecin , Optical imaging , Biodistribution , Tolerability , Cancer
Copyrigths: Cerrado
Source:
Journal of Controlled Release. (issn: 0168-3659 )
DOI: 10.1016/j.jconrel.2011.06.039
Publisher:
Elsevier
Publisher version: http://doi.org/10.1016/j.jconrel.2011.06.039
Thanks:
This work was financially supported by "Comision Interministerial de Ciencia y Tecnologia" of Spain (project MAT2006-14274-C02-01 to A. C.), Spanish National Research Council (project 200880I092 to P. B.) and grants from ...[+]
Type: Artículo

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