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dc.contributor.author | Compañ Moreno, Vicente | es_ES |
dc.contributor.author | Aguilella-Arzo, M. | es_ES |
dc.contributor.author | Del Castillo, L.F. | es_ES |
dc.contributor.author | Hernández, S.I. | es_ES |
dc.contributor.author | Gonzalez-Meijome, J.M. | es_ES |
dc.date.accessioned | 2018-07-09T04:27:55Z | |
dc.date.available | 2018-07-09T04:27:55Z | |
dc.date.issued | 2016 | es_ES |
dc.identifier.issn | 1552-4973 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/105512 | |
dc.description.abstract | [EN] This work is an analysis of the application of the generalized Monod kinetics model describing human corneal oxygen consumption during soft contact lens wear to models previously used by Chhabra et al. (J Biomed Mater Res B Appl Biomater, 2009a;90:202-209, Optom Vis Sci 2009b;86:454-466) and Larrea and Buchler (Invest Ophthalmol Vis Sci 2009;50:1076-1080). We use oxygen tension from in vivo estimations provided by Bonanno [Bonanno et al., Invest Ophthalmol Vis Sci 2002;43:371-376, and Bonanno et al 2009]. We consider four hydrogel and six silicone hydrogel lenses. The cornea is considered a single homogeneous layer, with constant oxygen permeability regardless of the type of lens worn. Our calculations yield different values for the maximum oxygen consumption rate Q(c,max), whith differents oxygen tensions (high and low p(c)) at the cornea-tears interface. Surprisingly, for both models, we observe an increase in oxygen consumption near an oxygen tension of 105 mmHg until a maximum is reached, then decreasing for higher levels of oxygen pressure. That is, when lowering the pressure of oxygen, the parameter Q(c,max) initially increases depending on the intensity of the change in pressure. Which, it could be related with the variation of the pH. Furthermore, it is also noted that to greater reductions in pressure, this parameter decreases, possibly due to changes in the concentration of glucose related to the anaerobic respiration. The averaged in vivo human corneal oxygen consumption rate of 1.47 x 10(-4) cm(3) of O-2/cm(3) tissue s, with Monod kinetics model, considering all the lenses studied, is smaller than the average oxygen consumption rate value obtained using the Larrea and Buchler model. The impact that these calculations have on the oxygen partial pressure available at different depths in the corneal tissue is presented and discussed, taking into consideration previous models used in this study. | es_ES |
dc.description.sponsorship | SIH is grateful to projects CONACYT SEP-2004-C01-47070, UNAM-DGAPA- PAPIIT IN113415, DGTIC-UNAM SC16-1-IR113, to the Red Tematica de la Materia Condensada BlandaCONACYT for a postdoctoral fellowship, and to CONACYT for a retention fellowship No. 207109. We thank Dr. Barry A. Weissman from the Southern California College of Optometry at Marshall B Ketchum University, Fullerton CA, USA for helpful comments and discussion. | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | John Wiley & Sons | es_ES |
dc.relation.ispartof | Journal of Biomedical Materials Research Part B Applied Biomaterials | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Soft contact lenses | es_ES |
dc.subject | Monod kinetics model | es_ES |
dc.subject | Oxygen consumption | es_ES |
dc.subject | Oxygen tension | es_ES |
dc.subject | Cornea | es_ES |
dc.subject.classification | FISICA APLICADA | es_ES |
dc.subject.classification | MAQUINAS Y MOTORES TERMICOS | es_ES |
dc.title | Analysis of the application of the Generalized Monod kinetics model to describe the Human Corneal Oxygen-Consumption Rate During Soft Contact Lens Wear | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1002/jbm.b.33764 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/CONACyT//SEP-2004-C01-4707/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/UNAM/PAPIIT/IN113415/MX/Termodinámica de no equilibrio de sistemas pequeños auto confinados/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/UNAM//DGTIC-UNAM SC16-1-IR113/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/CONACyT//207109/ | |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada | es_ES |
dc.description.bibliographicCitation | Compañ Moreno, V.; Aguilella-Arzo, M.; Del Castillo, L.; Hernández, S.; Gonzalez-Meijome, J. (2016). Analysis of the application of the Generalized Monod kinetics model to describe the Human Corneal Oxygen-Consumption Rate During Soft Contact Lens Wear. Journal of Biomedical Materials Research Part B Applied Biomaterials. 105(4):2269-2281. https://doi.org/10.1002/jbm.b.33764 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1002/jbm.b.33764 | es_ES |
dc.description.upvformatpinicio | 2269 | es_ES |
dc.description.upvformatpfin | 2281 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 105 | es_ES |
dc.description.issue | 4 | es_ES |
dc.relation.pasarela | S\324225 | es_ES |
dc.contributor.funder | Consejo Nacional de Ciencia y Tecnología, México | |
dc.contributor.funder | Universidad Nacional Autónoma de México |