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Analysis of the application of the Generalized Monod kinetics model to describe the Human Corneal Oxygen-Consumption Rate During Soft Contact Lens Wear

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Analysis of the application of the Generalized Monod kinetics model to describe the Human Corneal Oxygen-Consumption Rate During Soft Contact Lens Wear

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dc.contributor.author Compañ Moreno, Vicente es_ES
dc.contributor.author Aguilella-Arzo, M. es_ES
dc.contributor.author Del Castillo, L.F. es_ES
dc.contributor.author Hernández, S.I. es_ES
dc.contributor.author Gonzalez-Meijome, J.M. es_ES
dc.date.accessioned 2018-07-09T04:27:55Z
dc.date.available 2018-07-09T04:27:55Z
dc.date.issued 2016 es_ES
dc.identifier.issn 1552-4973 es_ES
dc.identifier.uri http://hdl.handle.net/10251/105512
dc.description.abstract [EN] This work is an analysis of the application of the generalized Monod kinetics model describing human corneal oxygen consumption during soft contact lens wear to models previously used by Chhabra et al. (J Biomed Mater Res B Appl Biomater, 2009a;90:202-209, Optom Vis Sci 2009b;86:454-466) and Larrea and Buchler (Invest Ophthalmol Vis Sci 2009;50:1076-1080). We use oxygen tension from in vivo estimations provided by Bonanno [Bonanno et al., Invest Ophthalmol Vis Sci 2002;43:371-376, and Bonanno et al 2009]. We consider four hydrogel and six silicone hydrogel lenses. The cornea is considered a single homogeneous layer, with constant oxygen permeability regardless of the type of lens worn. Our calculations yield different values for the maximum oxygen consumption rate Q(c,max), whith differents oxygen tensions (high and low p(c)) at the cornea-tears interface. Surprisingly, for both models, we observe an increase in oxygen consumption near an oxygen tension of 105 mmHg until a maximum is reached, then decreasing for higher levels of oxygen pressure. That is, when lowering the pressure of oxygen, the parameter Q(c,max) initially increases depending on the intensity of the change in pressure. Which, it could be related with the variation of the pH. Furthermore, it is also noted that to greater reductions in pressure, this parameter decreases, possibly due to changes in the concentration of glucose related to the anaerobic respiration. The averaged in vivo human corneal oxygen consumption rate of 1.47 x 10(-4) cm(3) of O-2/cm(3) tissue s, with Monod kinetics model, considering all the lenses studied, is smaller than the average oxygen consumption rate value obtained using the Larrea and Buchler model. The impact that these calculations have on the oxygen partial pressure available at different depths in the corneal tissue is presented and discussed, taking into consideration previous models used in this study. es_ES
dc.description.sponsorship SIH is grateful to projects CONACYT SEP-2004-C01-47070, UNAM-DGAPA- PAPIIT IN113415, DGTIC-UNAM SC16-1-IR113, to the Red Tematica de la Materia Condensada BlandaCONACYT for a postdoctoral fellowship, and to CONACYT for a retention fellowship No. 207109. We thank Dr. Barry A. Weissman from the Southern California College of Optometry at Marshall B Ketchum University, Fullerton CA, USA for helpful comments and discussion. en_EN
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation CONACYT/SEP-2004-C01-4707
dc.relation UNAM/UNAM-DGAPA- PAPIIT IN113415
dc.relation UNAM/DGTIC-UNAM SC16-1-IR113
dc.relation CONACYT/207109
dc.relation.ispartof Journal of Biomedical Materials Research Part B Applied Biomaterials es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Soft contact lenses es_ES
dc.subject Monod kinetics model es_ES
dc.subject Oxygen consumption es_ES
dc.subject Oxygen tension es_ES
dc.subject Cornea es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Analysis of the application of the Generalized Monod kinetics model to describe the Human Corneal Oxygen-Consumption Rate During Soft Contact Lens Wear es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/jbm.b.33764 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Compañ Moreno, V.; Aguilella-Arzo, M.; Del Castillo, L.; Hernández, S.; Gonzalez-Meijome, J. (2016). Analysis of the application of the Generalized Monod kinetics model to describe the Human Corneal Oxygen-Consumption Rate During Soft Contact Lens Wear. Journal of Biomedical Materials Research Part B Applied Biomaterials. 105(4):2269-2281. doi:10.1002/jbm.b.33764 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/jbm.b.33764 es_ES
dc.description.upvformatpinicio 2269 es_ES
dc.description.upvformatpfin 2281 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 105 es_ES
dc.description.issue 4 es_ES
dc.relation.pasarela S\324225 es_ES
dc.contributor.funder Consejo Nacional de Ciencia y Tecnología, México
dc.contributor.funder Universidad Nacional Autónoma de México


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