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Photo(geno)toxicity changes associated with hydroxylation of the aromatic chromophores during diclofenac metabolism

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Photo(geno)toxicity changes associated with hydroxylation of the aromatic chromophores during diclofenac metabolism

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García -Laínez, G.; Ana M Marínez-Reig; Limones Herrero, D.; Jiménez Molero, MC.; Miranda Alonso, MÁ.; Andreu Ros, MI. (2018). Photo(geno)toxicity changes associated with hydroxylation of the aromatic chromophores during diclofenac metabolism. Toxicology and Applied Pharmacology. 341:51-55. doi:10.1016/j.taap.2018.01.005

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Title: Photo(geno)toxicity changes associated with hydroxylation of the aromatic chromophores during diclofenac metabolism
Author:
UPV Unit: Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
Universitat Politècnica de València. Departamento de Química - Departament de Química
Issued date:
Embargo end date: 2019-02-15
Abstract:
[EN] Diclofenac (DCF) can cause adverse reactions such as gastrointestinal, renal and cardiovascular disorders; therefore, topical administration may be an attractive alternative to the management of local pain in order ...[+]
Subjects: Comet assay , DNA repair capability, Metabolites , Photosensitized DNA damage , Phototoxicity
Copyrigths: Reserva de todos los derechos
Source:
Toxicology and Applied Pharmacology. (issn: 0041-008X )
DOI: 10.1016/j.taap.2018.01.005
Publisher:
Elsevier
Publisher version: https://doi.org/10.1016/j.taap.2018.01.005
Thanks:
This work was supported by the Carlos III Institute of Health (Grants: RD16/0006/0030, PI16/01877), by the MINECO (Grants: CTQ2013-47872, CTQ2016-78875), and by the Generalitat Valenciana (Prometeo 2017/075).
Type: Artículo

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