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PCL-coated hydroxyapatite scaffold derived from cuttlefish bone: Morphology, mechanical properties and bioactivity

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PCL-coated hydroxyapatite scaffold derived from cuttlefish bone: Morphology, mechanical properties and bioactivity

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dc.contributor.author Milovac, Dajana es_ES
dc.contributor.author Gallego Ferrer, Gloria es_ES
dc.contributor.author Ivankovic, Marica es_ES
dc.contributor.author Ivankovic, Hrvoje es_ES
dc.date.accessioned 2018-07-16T06:57:57Z
dc.date.available 2018-07-16T06:57:57Z
dc.date.issued 2014 es_ES
dc.identifier.issn 0928-4931 es_ES
dc.identifier.uri http://hdl.handle.net/10251/105857
dc.description.abstract [EN] In the present study, poly(epsilon-caprolactone)-coated hydroxyapatite scaffold derived from cuttlefish bone was prepared. Hydrothermal transformation of aragonitic cuttlefish bone into hydroxyapatite (HAp) was performed at 200 C retaining the cuttlebone architecture. The HAp scaffold was coated with a poly(c-caprolactone) (PCL) using vacuum impregnation technique. The compositional and morphological properties of HAp and PCL-coated HAp scaffolds were studied by means of X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA) and scanning electron microscopy (SEM) with energy dispersive X-ray (EDX) analysis. Bioactivity was tested by immersion in Hank's balanced salt solution (HBSS) and mechanical tests were performed at compression. The results showed that PCL-coated HAp (HAp/PCL) scaffold resulted in a material with improved mechanical properties that keep the original interconnected porous structure indispensable for tissue growth and vascularization. The compressive strength (0.88 MPa) and the elastic modulus (15.5 MPa) are within the lower range of properties reported for human trabecular bones. The in vitro mineralization of calcium phosphate (CP) that produces the bone-like apatite was observed on both the pure HAp scaffold and the HAp/PCL composite scaffold. The prepared bioactive scaffold with enhanced mechanical properties is a good candidate for bone tissue engineering applications. es_ES
dc.description.sponsorship The financial support of the Ministry of Science, Education and Sports of the Republic of Croatia (project 125-1252970-3005: "Bioceramic, Polymer and Composite Nanostructured Materials") and from the Spanish Ministry project DPI2010-20399-C04-03 is gratefully acknowledged. Rocio Ochoa-Fernandez is also acknowledged for her help with the mechanical tests. en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation info:eu-repo/grantAgreement/MICINN//DPI2010-20399-C04-03/ES/DISEÑO Y FABRICACION DE UNA PLATAFORMA BIOMIMETICA TIPO SCAFFOLD%2FSOPORTE PARA LA REGENERACION DEL CARTILAGO ARTICULAR/ es_ES
dc.relation.ispartof Materials Science and Engineering C es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Poly(epsilon-caprolactone) es_ES
dc.subject Hydroxyapatite es_ES
dc.subject Scaffold es_ES
dc.subject Tissue engineering es_ES
dc.subject Mechanical properties es_ES
dc.subject Bioactivity es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title PCL-coated hydroxyapatite scaffold derived from cuttlefish bone: Morphology, mechanical properties and bioactivity es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.msec.2013.09.036 es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Milovac, D.; Gallego Ferrer, G.; Ivankovic, M.; Ivankovic, H. (2014). PCL-coated hydroxyapatite scaffold derived from cuttlefish bone: Morphology, mechanical properties and bioactivity. Materials Science and Engineering C. 34:437-445. https://doi.org/10.1016/j.msec.2013.09.036 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.msec.2013.09.036 es_ES
dc.description.upvformatpinicio 437 es_ES
dc.description.upvformatpfin 445 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 34 es_ES
dc.relation.pasarela S\285321 es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES


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