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Biostable scaffolds of polyacrylate polymers implanted in the articular cartilage induce hyaline-like cartilage regeneration in rabbits

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Biostable scaffolds of polyacrylate polymers implanted in the articular cartilage induce hyaline-like cartilage regeneration in rabbits

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dc.contributor.author Sancho-Tello, María es_ES
dc.contributor.author Forriol, Francisco es_ES
dc.contributor.author Martín de Llano, José J. es_ES
dc.contributor.author Antolinos Turpín, Carmen María es_ES
dc.contributor.author Gómez-Tejedor, José-Antonio es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.contributor.author Carda, Carmen es_ES
dc.date.accessioned 2018-07-17T05:49:57Z
dc.date.available 2018-07-17T05:49:57Z
dc.date.issued 2017 es_ES
dc.identifier.issn 0391-3988 es_ES
dc.identifier.uri http://hdl.handle.net/10251/105922
dc.description.abstract [EN] Purpose: To study the influence of scaffold properties on the organization of ¿in vivo¿ cartilage regeneration. Our hypothesis is that stress transmission to the cells seeded inside the scaffold pores or surrounding it, which is highly dependent on the scaffold properties, determine differentiation of both mesenchymal cells and dedifferentiated autologous chondrocytes. Methods: Four series of porous scaffolds made of different polyacrylate polymers, previously seeded with cultured rabbit chondrocytes or without cells preseeded, were implanted in cartilage defects in rabbits. Subchondral bone was always injured during the surgery in order to allow blood to reach the implantation site and fill scaffold pores. Results: Three months after implant, excellent tissue regeneration was obtained, with a well-organized layer of hyaline cartilage at the condylar surface in most cases of the hydrophobic or slightly hydrophilic series. The most hydrophilic material induced the poorest regeneration. However, few variations were observed between the preseeded and non-preseeded scaffolds. All the materials employed were biocompatible, biostable polymers, therefore, in contrast to other studies, our results are not perturbed by possible effects attributable to material degradation products, or to the loss of scaffold mechanical properties over time due to degradation. Conclusions: Cartilage regeneration mainly depends on the properties of the scaffold, such as stiffness and hydrophility, whereas little differences were observed between preseeded and non-preseeded scaffolds. es_ES
dc.description.sponsorship Supported by the Ministry of Economy and Competitiveness through project No. MAT2013-46467-C4-R, including the FEDER financial support. CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program. CIBER Actions are financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. es_ES
dc.language Inglés es_ES
dc.publisher Wichtig Publishing es_ES
dc.relation info:eu-repo/grantAgreement/MINECO//MAT2013-46467-C4-1-R/ES/ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA/ es_ES
dc.relation.ispartof The International Journal of Artificial Organs es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Animal models es_ES
dc.subject Biopolymers es_ES
dc.subject Cartilage es_ES
dc.subject Scaffolds es_ES
dc.subject Tissue engineering es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Biostable scaffolds of polyacrylate polymers implanted in the articular cartilage induce hyaline-like cartilage regeneration in rabbits es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.5301/ijao.5000598 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Sancho-Tello, M.; Forriol, F.; Martín De Llano, JJ.; Antolinos Turpín, CM.; Gómez-Tejedor, J.; Gómez Ribelles, JL.; Carda, C. (2017). Biostable scaffolds of polyacrylate polymers implanted in the articular cartilage induce hyaline-like cartilage regeneration in rabbits. The International Journal of Artificial Organs. 40(7):350-357. https://doi.org/10.5301/ijao.5000598 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.5301/ijao.5000598 es_ES
dc.description.upvformatpinicio 350 es_ES
dc.description.upvformatpfin 357 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 40 es_ES
dc.description.issue 7 es_ES
dc.identifier.pmid 28574106 es_ES
dc.identifier.pmcid PMC6379805 es_ES
dc.relation.pasarela S\349158 es_ES
dc.contributor.funder Ministerio de Economía, Industria y Competitividad es_ES


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