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Modelling drug effects on personalized 3D models of the heart: a simulation study

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Modelling drug effects on personalized 3D models of the heart: a simulation study

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dc.contributor.author Sebastian, Rafael es_ES
dc.contributor.author Heidenreich, Elvio es_ES
dc.contributor.author Dux-Santoy Hurtado, Lydia es_ES
dc.contributor.author Rodriguez, Jose F. es_ES
dc.contributor.author Ferrero De Loma-Osorio, José María es_ES
dc.contributor.author Saiz Rodríguez, Francisco Javier es_ES
dc.date.accessioned 2018-09-17T06:51:24Z
dc.date.available 2018-09-17T06:51:24Z
dc.date.issued 2010 es_ES
dc.identifier.issn 0302-9743 es_ES
dc.identifier.uri http://hdl.handle.net/10251/107322
dc.description.abstract [EN] The use of anti-arrhythmic drugs is common to treat heart rhythm disorders. Computational modeling and simulation are powerful tools that can be used to investigate the effects of specific drugs on cardiac electrophysiology. In this work a patient-specific anatomical heart model is built to study the effects of dofetilide, a drug that affects IKr current in cardiac cells. We study the multi-scale effects of the drug, from cellular to organ level, by simulating electrical propagation on tissue coupled cellular ion kinetics for several heart beats. Different cell populations configurations namely endocardial, midmyocardial and epicardial are used to test the effect of tissue heterogeneity. Results confirmed the expected effects of dofetilide at cellular level, increasing the action potential duration. Pseudo-ECGs obtained for each heart beat correlated well with cellular results showing prolongation of QT segment. These techniques can be applied over the development of more complex drugs that affect multiple cellular currents. es_ES
dc.description.sponsorship This work has been partially funded by the Ministerio de Ciencia e Innovacion,TEC-2008-02090. es_ES
dc.language Inglés es_ES
dc.publisher Springer-Verlag es_ES
dc.relation.ispartof Lecture Notes in Computer Science es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Modelling drug effects on personalized 3D models of the heart: a simulation study es_ES
dc.type Artículo es_ES
dc.type Comunicación en congreso es_ES
dc.identifier.doi 10.1007/978-3-642-15835-3_23 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//TEC2008-02090/ES/MODELO MULTI-ESCALA DEL CORAZON. APLICACION EN LA PREVENCION, DIAGNOSTICO Y TRATAMIENTO DE ARRITMIAS CARDIACAS/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Sebastian, R.; Heidenreich, E.; Dux-Santoy Hurtado, L.; Rodriguez, JF.; Ferrero De Loma-Osorio, JM.; Saiz Rodríguez, FJ. (2010). Modelling drug effects on personalized 3D models of the heart: a simulation study. Lecture Notes in Computer Science. 6364:222-231. https://doi.org/10.1007/978-3-642-15835-3_23 es_ES
dc.description.accrualMethod S es_ES
dc.relation.conferencename 1st International Workshop on Statistical Atlases and Computational Models of the Heart es_ES
dc.relation.conferencedate Septiembre 10-10,2010 es_ES
dc.relation.conferenceplace Beijing, China es_ES
dc.relation.publisherversion https://doi.org/10.1007/978-3-642-15835-3_23 es_ES
dc.description.upvformatpinicio 222 es_ES
dc.description.upvformatpfin 231 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 6364 es_ES
dc.relation.pasarela S\222458 es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
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