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dc.contributor.author | Gamboa-Martinez, Tatiana Carolina | es_ES |
dc.contributor.author | Luque-Guillen, Victoria | es_ES |
dc.contributor.author | González-García, Cristina | es_ES |
dc.contributor.author | Gómez Ribelles, José Luís | es_ES |
dc.contributor.author | Gallego-Ferrer, Gloria | es_ES |
dc.date.accessioned | 2018-09-17T06:52:15Z | |
dc.date.available | 2018-09-17T06:52:15Z | |
dc.date.issued | 2015 | es_ES |
dc.identifier.issn | 1549-3296 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/107326 | |
dc.description.abstract | [EN] Fibrin is a protein that can be used as an ideal scaffolding material to promote tissue regeneration. In order to enhance its physical properties in this study a natural crosslinker, genipin (GP), was employed with the aim to obtain a hydrogel with tuneable properties for tissue engineering applications. The fibrin gel was crosslinked by two different methods using four concentrations of GP to get a stable hydrogel network. Crosslinking density, mechanical properties, swelling, and enzymatic degradation of the hydrogels were tested for each GP content and method employed. The method I: Crosslinking after gel formation promotes a high crosslinking and retains the gel shape for long term whilst the method II: Simultaneous gel formation and crosslinking improves the mechanical properties of the gel. This study confirms the use of GP at different concentrations as a suitable crosslinker of fibrin that promotes the cellular viability of L929 for 21 days of in vitro culture. | es_ES |
dc.description.sponsorship | Contract grant sponsor: Ciber-BBN, Instituto de Salud Carlos III, European Regional Development Fund | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | John Wiley & Sons | es_ES |
dc.relation.ispartof | Journal of Biomedical Materials Research Part A | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Fibrin | es_ES |
dc.subject | Genipin | es_ES |
dc.subject | Hydrogel | es_ES |
dc.subject | Natural crosslinker | es_ES |
dc.subject | Tissue engineering | es_ES |
dc.subject.classification | MAQUINAS Y MOTORES TERMICOS | es_ES |
dc.title | Crosslinked fibrin gels for tissue engineering: Two approaches to improve their properties | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1002/jbm.a.35210 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/324386/EU/Network for Development of Soft Nanofibrous Construct for Cellular Therapy of Degenerative Skeletal Disorders/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/ERA-Net EuroNanoMed 2011/PI11/03032/ | |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada | es_ES |
dc.description.bibliographicCitation | Gamboa-Martinez, TC.; Luque-Guillen, V.; González-García, C.; Gómez Ribelles, JL.; Gallego-Ferrer, G. (2015). Crosslinked fibrin gels for tissue engineering: Two approaches to improve their properties. Journal of Biomedical Materials Research Part A. 103(2):614-621. https://doi.org/10.1002/jbm.a.35210 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1002/jbm.a.35210 | es_ES |
dc.description.upvformatpinicio | 614 | es_ES |
dc.description.upvformatpfin | 621 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 103 | es_ES |
dc.description.issue | 2 | es_ES |
dc.relation.pasarela | S\285322 | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | European Commission | |
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