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Crosslinked fibrin gels for tissue engineering: Two approaches to improve their properties

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Crosslinked fibrin gels for tissue engineering: Two approaches to improve their properties

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dc.contributor.author Gamboa-Martinez, Tatiana Carolina es_ES
dc.contributor.author Luque-Guillen, Victoria es_ES
dc.contributor.author González-García, Cristina es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.contributor.author Gallego-Ferrer, Gloria es_ES
dc.date.accessioned 2018-09-17T06:52:15Z
dc.date.available 2018-09-17T06:52:15Z
dc.date.issued 2015 es_ES
dc.identifier.issn 1549-3296 es_ES
dc.identifier.uri http://hdl.handle.net/10251/107326
dc.description.abstract [EN] Fibrin is a protein that can be used as an ideal scaffolding material to promote tissue regeneration. In order to enhance its physical properties in this study a natural crosslinker, genipin (GP), was employed with the aim to obtain a hydrogel with tuneable properties for tissue engineering applications. The fibrin gel was crosslinked by two different methods using four concentrations of GP to get a stable hydrogel network. Crosslinking density, mechanical properties, swelling, and enzymatic degradation of the hydrogels were tested for each GP content and method employed. The method I: Crosslinking after gel formation promotes a high crosslinking and retains the gel shape for long term whilst the method II: Simultaneous gel formation and crosslinking improves the mechanical properties of the gel. This study confirms the use of GP at different concentrations as a suitable crosslinker of fibrin that promotes the cellular viability of L929 for 21 days of in vitro culture. es_ES
dc.description.sponsorship Contract grant sponsor: Ciber-BBN, Instituto de Salud Carlos III, European Regional Development Fund en_EN
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation.ispartof Journal of Biomedical Materials Research Part A es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Fibrin es_ES
dc.subject Genipin es_ES
dc.subject Hydrogel es_ES
dc.subject Natural crosslinker es_ES
dc.subject Tissue engineering es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Crosslinked fibrin gels for tissue engineering: Two approaches to improve their properties es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/jbm.a.35210 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/324386/EU/Network for Development of Soft Nanofibrous Construct for Cellular Therapy of Degenerative Skeletal Disorders/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/ERA-Net EuroNanoMed 2011/PI11/03032/
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Gamboa-Martinez, TC.; Luque-Guillen, V.; González-García, C.; Gómez Ribelles, JL.; Gallego-Ferrer, G. (2015). Crosslinked fibrin gels for tissue engineering: Two approaches to improve their properties. Journal of Biomedical Materials Research Part A. 103(2):614-621. https://doi.org/10.1002/jbm.a.35210 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/jbm.a.35210 es_ES
dc.description.upvformatpinicio 614 es_ES
dc.description.upvformatpfin 621 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 103 es_ES
dc.description.issue 2 es_ES
dc.relation.pasarela S\285322 es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina es_ES
dc.contributor.funder Instituto de Salud Carlos III
dc.contributor.funder European Commission
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