- -

In vitro mechanical fatigue behavior of poly-epsilon-caprolactone macroporous scaffolds for cartilage tissue engineering: Influence of pore filling by a poly(vinyl alcohol) gel

RiuNet: Institutional repository of the Polithecnic University of Valencia

Share/Send to

Cited by

Statistics

  • Estadisticas de Uso

In vitro mechanical fatigue behavior of poly-epsilon-caprolactone macroporous scaffolds for cartilage tissue engineering: Influence of pore filling by a poly(vinyl alcohol) gel

Show simple item record

Files in this item

dc.contributor.author Panadero, Juan Alberto es_ES
dc.contributor.author Vikingsson, Line es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.contributor.author Lanceros-Mendez, S. es_ES
dc.contributor.author Sencadas, V. es_ES
dc.date.accessioned 2018-09-17T06:54:30Z
dc.date.available 2018-09-17T06:54:30Z
dc.date.issued 2015 es_ES
dc.identifier.issn 1552-4973 es_ES
dc.identifier.uri http://hdl.handle.net/10251/107332
dc.description.abstract [EN] Polymeric scaffolds used in regenerative therapies are implanted in the damaged tissue and submitted to repeated loading cycles. In the case of articular cartilage engineering, an implanted scaffold is typically subjected to long-term dynamic compression. The evolution of the mechanical properties of the scaffold during bioresorption has been deeply studied in the past, but the possibility of failure due to mechanical fatigue has not been properly addressed. Nevertheless, the macroporous scaffold is susceptible to failure after repeated loading-unloading cycles. In this work fatigue studies of polycaprolactone scaffolds were carried by subjecting the scaffold to repeated compression cycles in conditions simulating the scaffold implanted in the articular cartilage. The behavior of the polycaprolactone sponge with the pores filled with a poly(vinyl alcohol) gel simulating the new formed tissue within the pores was compared with that of the material immersed in water. Results were analyzed with Morrow's criteria for failure and accurate fittings are obtained just up to 200 loading cycles. It is also shown that the presence of poly(vinyl alcohol) increases the elastic modulus of the scaffolds, the effect being more pronounced with increasing the number of freeze/thawing cycles. es_ES
dc.description.sponsorship Contract grant sponsor: FCT; contract grant number: SFRH/BD/64586/2009 and SFRH/BPD/63148/2009 MINECO, contract grant MAT2013-46467-C4-1-R en_EN
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation.ispartof Journal of Biomedical Materials Research Part B Applied Biomaterials es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Fatigue es_ES
dc.subject Mechanical properties es_ES
dc.subject Microstructure es_ES
dc.subject Porous es_ES
dc.subject Scaffolds es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title In vitro mechanical fatigue behavior of poly-epsilon-caprolactone macroporous scaffolds for cartilage tissue engineering: Influence of pore filling by a poly(vinyl alcohol) gel es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/jbm.b.33276 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2013-46467-C4-1-R/ES/ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/FCT/SFRH/SFRH/BD/64586/2009/PT/ en_EN
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Panadero, JA.; Vikingsson, L.; Gómez Ribelles, JL.; Lanceros-Mendez, S.; Sencadas, V. (2015). In vitro mechanical fatigue behavior of poly-epsilon-caprolactone macroporous scaffolds for cartilage tissue engineering: Influence of pore filling by a poly(vinyl alcohol) gel. Journal of Biomedical Materials Research Part B Applied Biomaterials. 103(5):1037-1043. https://doi.org/10.1002/jbm.b.33276 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/jbm.b.33276 es_ES
dc.description.upvformatpinicio 1037 es_ES
dc.description.upvformatpfin 1043 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 103 es_ES
dc.description.issue 5 es_ES
dc.relation.pasarela S\299905 es_ES
dc.contributor.funder Ministerio de Economía, Industria y Competitividad es_ES


This item appears in the following Collection(s)

Show simple item record