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Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease.

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Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease.

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dc.contributor.author Pascual-Ahuir Giner, María Desamparados es_ES
dc.contributor.author Manzanares-Estreder, Sara es_ES
dc.contributor.author Proft, Markus es_ES
dc.date.accessioned 2018-09-17T08:18:35Z
dc.date.available 2018-09-17T08:18:35Z
dc.date.issued 2017 es_ES
dc.identifier.issn 1942-0900 es_ES
dc.identifier.uri http://hdl.handle.net/10251/107428
dc.description.abstract [EN] Peroxisomes and mitochondria are the main intracellular sources for reactive oxygen species. At the same time, both organelles are critical for the maintenance of a healthy redox balance in the cell. Consequently, failure in the function of both organelles is causally linked to oxidative stress and accelerated aging. However, it has become clear that peroxisomes and mitochondria are much more intimately connected both physiologically and structurally. Both organelles share common fission components to dynamically respond to environmental cues, and the autophagic turnover of both peroxisomes and mitochondria is decisive for cellular homeostasis. Moreover, peroxisomes can physically associate with mitochondria via specific protein complexes. Therefore, the structural and functional connection of both organelles is a critical and dynamic feature in the regulation of oxidative metabolism, whose dynamic nature will be revealed in the future. In this review, we will focus on fundamental aspects of the peroxisome-mitochondria interplay derived from simple models such as yeast and move onto discussing the impact of an impaired peroxisomal and mitochondrial homeostasis on ROS production, aging, and disease in humans. es_ES
dc.language Inglés es_ES
dc.publisher Hindawi Limited es_ES
dc.relation Ministerio de Economía y Competitividad/BFU2016-75792-R es_ES
dc.relation micinn/BFU2011-23326 es_ES
dc.relation.ispartof Oxidative Medicine and Cellular Longevity es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject.classification BIOQUIMICA Y BIOLOGIA MOLECULAR es_ES
dc.title Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease. es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1155/2017/9860841 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation Pascual-Ahuir Giner, MD.; Manzanares-Estreder, S.; Proft, M. (2017). Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease. Oxidative Medicine and Cellular Longevity. (9860841). doi:10.1155/2017/9860841 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1155/2017/9860841 es_ES
dc.type.version info:eu repo/semantics/publishedVersion es_ES
dc.description.issue 9860841 es_ES
dc.identifier.pmid 28811869 en_EN
dc.identifier.pmcid PMC5546064 en_EN
dc.relation.pasarela 354213 es_ES
dc.contributor.funder micinn es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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