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Electrospun PVA/Bentonite Nanocomposites Mats for Drug Delivery

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Electrospun PVA/Bentonite Nanocomposites Mats for Drug Delivery

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dc.contributor.author Ferrández-Rives, M. es_ES
dc.contributor.author Beltrán-Osuna, A.A. es_ES
dc.contributor.author Gómez-Tejedor, José Antonio es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.date.accessioned 2018-09-25T07:38:41Z
dc.date.available 2018-09-25T07:38:41Z
dc.date.issued 2017 es_ES
dc.identifier.uri http://hdl.handle.net/10251/108080
dc.description.abstract [EN] Electrospun mats and films of polyvinyl alcohol (PVA) hydrogel are produced for drug delivery. To provide mechanical consistency to the gel a reinforcement by nanoclays is introduced in the polymer matrix. Four different suspensions of nanoparticles in the polymer solution are prepared in an adequate solvent. These suspensions are subjected to an electrospinning process to produce the nanofiber mat, while films are produced by casting. The influence of the process parameters over the nanofibers microstructure is analyzed by scanning electron microscopy (SEM). The effectiveness of nanoclay encapsulation in the nanocomposites is tested by a thermogravimetric analysis. A crosslinking reaction in solution is carried out to prevent the dissolution of the nanocomposites in aqueous media. A model protein (bovine serum albumin, BSA) is absorbed in the nanocomposites to characterize the release kinetics in phosphate-buffered saline (PBS). es_ES
dc.description.sponsorship The authors gratefully acknowledge the technical assistance of Yesenia Gonzalez in sample preparation and sorption experiments, Professor Ramon Martinez Manez and his research group from the Laboratory of Nanomedicine, at the Institute of Applied Molecular Chemistry (IQMA) for their support in the DLS measurements and the assistance and advice of Electron Microscopy Service of the UPV. This work was funded by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016-76039-C4-1-R (including the FEDER financial support) CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund.
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation AEI/MAT2016-76039-C4-1-R es_ES
dc.relation.ispartof Materials es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Polyvinyl alcohol es_ES
dc.subject Electrospinning es_ES
dc.subject Crosslinking es_ES
dc.subject Nanoclay es_ES
dc.subject Drug delivery es_ES
dc.subject Electron Microscopy Service of the UPV
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Electrospun PVA/Bentonite Nanocomposites Mats for Drug Delivery es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/ma10121448 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Ferrández-Rives, M.; Beltrán-Osuna, A.; Gómez-Tejedor, JA.; Gómez Ribelles, JL. (2017). Electrospun PVA/Bentonite Nanocomposites Mats for Drug Delivery. Materials. 10(12). doi:10.3390/ma10121448 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.3390/ma10121448 es_ES
dc.description.upvformatpinicio 1448 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 10 es_ES
dc.description.issue 12 es_ES
dc.identifier.eissn 1996-1944 es_ES
dc.identifier.pmid 29261123 en_EN
dc.identifier.pmcid PMC5744383 en_EN
dc.relation.pasarela S\349161 es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES


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