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Human Mesenchymal Stem Cells Differentiation Regulated by Hydroxyapatite Content within Chitosan-Based Scaffolds under Perfusion Conditions

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Human Mesenchymal Stem Cells Differentiation Regulated by Hydroxyapatite Content within Chitosan-Based Scaffolds under Perfusion Conditions

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dc.contributor.author Rogina, Anamarija es_ES
dc.contributor.author Antunovic, Maja es_ES
dc.contributor.author Pribol an, Lidija es_ES
dc.contributor.author Mihalic, Katarina Caput es_ES
dc.contributor.author Vukasovic, Andreja es_ES
dc.contributor.author Ivkovic, Alan es_ES
dc.contributor.author Marijanovic, Inga es_ES
dc.contributor.author Gallego-Ferrer, Gloria es_ES
dc.contributor.author Ivankovic, Marica es_ES
dc.contributor.author Ivankovic, Hrvoje es_ES
dc.date.accessioned 2018-09-25T07:39:13Z
dc.date.available 2018-09-25T07:39:13Z
dc.date.issued 2017 es_ES
dc.identifier.uri http://hdl.handle.net/10251/108081
dc.description.abstract [EN] The extensive need for hard tissue substituent greatly motivates development of suitable allogeneic grafts for therapeutic recreation. Different calcium phosphate phases have been accepted as scaffold's components with positive influence on osteoinduction and differentiation of human mesenchymal stem cells, in terms of their higher fraction within the graft. Nevertheless, the creation of unlimited nutrients diffusion through newly formed grafts is of great importance. The media flow accomplished by perfusion forces can provide physicochemical, and also, biomechanical stimuli for three-dimensional bone-construct growth. In the present study, the influence of a different scaffold's composition on the human mesenchymal stem cells (hMSCs) differentiation performed in a U-CUP bioreactor under perfusion conditioning was investigated. The histological and immunohistochemical analysis of cultured bony tissues, and the evaluation of osteogenic genes' expression indicate that the lower fraction of in situ formed hydroxyapatite in the range of 10-30% within chitosan scaffold could be preferable for bone-construct development. es_ES
dc.description.sponsorship BICRO PoC5_1_82, the Croatian Science Foundation under the project IP-2014-09-3752 and L'Oreal-UNESCO Foundation 'ForWomen in Science' are gratefully acknowledged. es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Polymers es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Chitosan es_ES
dc.subject Hydroxyapatite es_ES
dc.subject hMSC's es_ES
dc.subject Perfusion-bioreactor es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Human Mesenchymal Stem Cells Differentiation Regulated by Hydroxyapatite Content within Chitosan-Based Scaffolds under Perfusion Conditions es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/polym9090387 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/HRZZ//IP-2014-09-3752/HR/Development of Biocompatible Hydroxyapatite Based Materials for Bone Tissue Engineering Applications/
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Rogina, A.; Antunovic, M.; Pribol An, L.; Mihalic, KC.; Vukasovic, A.; Ivkovic, A.; Marijanovic, I.... (2017). Human Mesenchymal Stem Cells Differentiation Regulated by Hydroxyapatite Content within Chitosan-Based Scaffolds under Perfusion Conditions. Polymers. 9(9):1-17. https://doi.org/10.3390/polym9090387 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/polym9090387 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 17 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 9 es_ES
dc.description.issue 9 es_ES
dc.identifier.eissn 2073-4360 es_ES
dc.relation.pasarela S\358858 es_ES
dc.contributor.funder Croatian Science Foundation
dc.contributor.funder L'Oréal-UNESCO Foundation


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