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Biodegradable chitosan-poly(epsilon-caprolactone) dialdehyde copolymer networks for soft tissue engineering

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Biodegradable chitosan-poly(epsilon-caprolactone) dialdehyde copolymer networks for soft tissue engineering

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dc.contributor.author Gámiz González, Mª Amparo es_ES
dc.contributor.author Vidaurre, Ana es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.date.accessioned 2018-09-25T07:43:31Z
dc.date.available 2018-09-25T07:43:31Z
dc.date.issued 2017 es_ES
dc.identifier.issn 0141-3910 es_ES
dc.identifier.uri http://hdl.handle.net/10251/108092
dc.description.abstract [EN] Chitosan/PCL block-copolymer networks were synthesized using different amounts of aldehyde end capped polycaprolactone as crosslinking agent. The crosslinking reaction was performed by dissolving both components in the common solvent hexafluoroisopropanol (HFIP). The formation of the network was confirmed by solubility tests in good solvents of both components. The resulting composition was determined by thermogravimetric analysis. The hydrophilic/hydrophobic networks behave as hydrogels; water sorption at pH7 is around 70% that of pure chitosan for a network containing 36% PCL blocks. The PCL domains were not able to crystallize, except for the CHT-64 sample as shown by DSC and X-ray diffraction. Enzymatic degradation of these networks is quite fast, thus, the network with 36% PCL presented a remaining weight of 22 +/- 1% of their initial mass after 28 days of degradation in lipase. Nevertheless in purely hydrolytic degradation, the remaining weight was 86+3% for the same time and composition. es_ES
dc.description.sponsorship The authors gratefully acknowledge the financial support from the Spanish Ministry of Economy and Competitiveness through the MAT2013-46467-C4-1-R and MAT2016-76039-C4-1-R Project, including FEDER funds. CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Institute de Salud Carlos III with the assistance of the European Regional Development Fund. MAGG acknowledges a grant from the BES-2011-044740. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Polymer Degradation and Stability es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Chitosan es_ES
dc.subject Block-copolymer network es_ES
dc.subject Thermal degradation es_ES
dc.subject Biodegradable polymer es_ES
dc.subject Lipase degradation es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.subject.classification TERMODINAMICA APLICADA (UPV) es_ES
dc.title Biodegradable chitosan-poly(epsilon-caprolactone) dialdehyde copolymer networks for soft tissue engineering es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.polymdegradstab.2017.02.005 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2013-46467-C4-1-R/ES/ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2016-76039-C4-1-R/ES/BIOMATERIALES PIEZOELECTRICOS PARA LA DIFERENCIACION CELULAR EN INTERFASES CELULA-MATERIAL ELECTRICAMENTE ACTIVAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO///MAT2016-76039-C4-1-R-R/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//BES-2011-044740/ES/BES-2011-044740/ es_ES
dc.rights.accessRights Abierto es_ES
dc.date.embargoEndDate 2019-04-30 es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Gámiz González, MA.; Vidaurre, A.; Gómez Ribelles, JL. (2017). Biodegradable chitosan-poly(epsilon-caprolactone) dialdehyde copolymer networks for soft tissue engineering. Polymer Degradation and Stability. 138:47-54. https://doi.org/10.1016/j.polymdegradstab.2017.02.005 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.polymdegradstab.2017.02.005 es_ES
dc.description.upvformatpinicio 47 es_ES
dc.description.upvformatpfin 54 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 138 es_ES
dc.relation.pasarela S\356572 es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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