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Polyurethane-based bioadhesive synthesized from polyols derived from castor oil (Ricinus communis) and low concentration of chitosan

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Polyurethane-based bioadhesive synthesized from polyols derived from castor oil (Ricinus communis) and low concentration of chitosan

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dc.contributor.author Uscátegui, Yomaira L. es_ES
dc.contributor.author Arevalo-Alquichire, Said J. es_ES
dc.contributor.author Gómez-Tejedor, José-Antonio es_ES
dc.contributor.author Vallés Lluch, Ana es_ES
dc.contributor.author Diaz, Luis E. es_ES
dc.contributor.author Valero, Manuel F. es_ES
dc.date.accessioned 2018-09-28T04:30:02Z
dc.date.available 2018-09-28T04:30:02Z
dc.date.issued 2017 es_ES
dc.identifier.issn 0884-2914 es_ES
dc.identifier.uri http://hdl.handle.net/10251/108466
dc.description.abstract [EN] Polyurethane-based bioadhesive was synthesized with polyols derived from castor oil (chemically modified and unmodified) and hexamethylene diisocyanate with chitosan addition as a bioactive filler. The objective was to evaluate the effect of type of polyols with the incorporation of low-concentrations of chitosan on the mechanical and biological properties of the polymer to obtain suitable materials in the design of biomaterials. The results showed that increasing physical crosslinking increased the mechanical and adhesive properties. An in vitro cytotoxic test of polyurethanes showed cellular viability. The biocompatibility of the polyurethanes favors the adhesion of L929 cells at 6, 24, and 48 h. The polyurethanes showed bacterial inhibition depending on the polyol and percentage of chitosan. The antibacterial effect of the polyurethanes for Escherichia coli decreased 60-90% after 24 h. The mechanical and adhesive properties together with biological response in this research suggested these polyurethanes as external application tissue bioadhesives. es_ES
dc.description.sponsorship This work was supported by the Universidad de La Sabana under grant number ING-176-2016 and by Colciencias under scholarship grant 617-2-2014. CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program. CIBER Actions are financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. J.A.G.T. and A.V.L. acknowledge the support of the Spanish Ministry of Economy and Competitiveness (MINECO) through project DPI2015-65401-C3-2-R (including FEDER financial support). Finally, the authors thank the Universitat Politecnica de Valencia for assistance and advice with the equipment. es_ES
dc.language Inglés es_ES
dc.publisher Cambridge University Press (Materials Research Society) es_ES
dc.relation MINISTERIO DE ECONOMIA INDUSTRIA Y COMPETITIVIDAD /DPI2015-65401-C3-2-R es_ES
dc.relation.ispartof Journal of Materials Research es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Polyurethane-based es_ES
dc.subject Bioadhesive es_ES
dc.subject Castor oili es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Polyurethane-based bioadhesive synthesized from polyols derived from castor oil (Ricinus communis) and low concentration of chitosan es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1557/jmr.2017.371 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Uscátegui, YL.; Arevalo-Alquichire, SJ.; Gómez-Tejedor, J.; Vallés Lluch, A.; Diaz, LE.; Valero, MF. (2017). Polyurethane-based bioadhesive synthesized from polyols derived from castor oil (Ricinus communis) and low concentration of chitosan. Journal of Materials Research. 32(19):3699-3711. doi:10.1557/jmr.2017.371 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1557/jmr.2017.371 es_ES
dc.description.upvformatpinicio 3699 es_ES
dc.description.upvformatpfin 3711 es_ES
dc.type.version info:eu repo/semantics/publishedVersion es_ES
dc.description.volume 32 es_ES
dc.description.issue 19 es_ES
dc.relation.pasarela 349184 es_ES
dc.contributor.funder MINISTERIO DE ECONOMIA INDUSTRIA Y COMPETITIVIDAD es_ES


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