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Emulsion based microencapsulation of proteins in poly(L-lactic acid) films and membranes for the controlled release of drugs

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Emulsion based microencapsulation of proteins in poly(L-lactic acid) films and membranes for the controlled release of drugs

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dc.contributor.author Delmote, Josephine es_ES
dc.contributor.author Teruel-Biosca, Laura es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.contributor.author Gallego-Ferrer, Gloria es_ES
dc.date.accessioned 2018-10-30T05:33:00Z
dc.date.available 2018-10-30T05:33:00Z
dc.date.issued 2017 es_ES
dc.identifier.issn 0141-3910 es_ES
dc.identifier.uri http://hdl.handle.net/10251/111526
dc.description.abstract [EN] The aim of this study was to develop micro- or macro-porous substrates of poly(L-lactic acid) (PLLA) for the sustained release of water-soluble proteins. A model protein, bovine serum albumin (BSA), was incorporated into the hydrophobous PLLA matrix by emulsifying an aqueous BSA solution into an organic PLEA solution. The work focused on the effect of the fabrication procedure on substrates' microstructure and protein delivery kinetics. The films were prepared by solvent casting or freeze-extraction, after which the protein release profiles from both matrices were compared. A homogeneous distribution of BSA in the PLLA-films and membranes was obtained. In vitro release of the protein from the freeze extraction membranes was more significant than the release from the solvent cast films. BSA was found to be released from the freeze-extraction membranes in two stages: an initial fast release followed by a sustained release. The release from the solvent cast films was more moderated and accompanied by the polymer degradation. es_ES
dc.description.sponsorship The authors are grateful for the financial support received from the Spanish Ministry through the MAT2016-76039-C4-1-R Project (including Feder funds). CIBER-BBN is an initiative funded by the VI National R&D&I plan 2008-2011, "Iniciativa Ingenio 2010", Consolider Program. CIBER actions are financed by the "Instituto de Salud Carlos III" with assistance from the European Regional Development Fund. The authors' thanks are also due to the "Servicio de Microscopic Electronica" of the "Universitat Politecnica de Valencia" for their valuable assistance. en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Polymer Degradation and Stability es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Poly(L-lactic acid) es_ES
dc.subject PLLA es_ES
dc.subject Freeze extraction es_ES
dc.subject Drug delivery es_ES
dc.subject w/o Emulsion es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Emulsion based microencapsulation of proteins in poly(L-lactic acid) films and membranes for the controlled release of drugs es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.polymdegradstab.2017.09.012 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2016-76039-C4-1-R/ES/BIOMATERIALES PIEZOELECTRICOS PARA LA DIFERENCIACION CELULAR EN INTERFASES CELULA-MATERIAL ELECTRICAMENTE ACTIVAS/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Delmote, J.; Teruel-Biosca, L.; Gómez Ribelles, JL.; Gallego-Ferrer, G. (2017). Emulsion based microencapsulation of proteins in poly(L-lactic acid) films and membranes for the controlled release of drugs. Polymer Degradation and Stability. 146:24-33. https://doi.org/10.1016/j.polymdegradstab.2017.09.012 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.polymdegradstab.2017.09.012 es_ES
dc.description.upvformatpinicio 24 es_ES
dc.description.upvformatpfin 33 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 146 es_ES
dc.relation.pasarela S\357750 es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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