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Drug-DNA complexation as the key factor in photosensitized thymine dimerization

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Drug-DNA complexation as the key factor in photosensitized thymine dimerization

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dc.contributor.author Cuquerella Alabort, Maria Consuelo es_ES
dc.contributor.author Lhiaubet, Virginie Lyria es_ES
dc.contributor.author Miranda Alonso, Miguel Ángel es_ES
dc.contributor.author Bosca Mayans, Francisco es_ES
dc.date.accessioned 2018-10-31T05:32:28Z
dc.date.available 2018-10-31T05:32:28Z
dc.date.issued 2017 es_ES
dc.identifier.issn 1463-9076 es_ES
dc.identifier.uri http://hdl.handle.net/10251/111604
dc.description.abstract [EN] The crucial role of photosensitizer@DNA complexation in the formation of cyclobutane pyrimidine dimers (CPDs) has been demonstrated using femtosecond and nanosecond transient absorption and emission measurements in combination with in vitro DNA damage assays. This finding opens the door to re-evaluate the mechanisms involved in CPDs photosensitized by other chemicals. es_ES
dc.description.sponsorship Spanish Government (CTQ2014-54729-C2-2-P, CTQ2015-70164-P and Severo Ochoa program/SEV-2012-0267) and Generalitat Valenciana (Prometeo II program) are gratefully acknowledged. en_EN
dc.language Inglés es_ES
dc.publisher The Royal Society of Chemistry es_ES
dc.relation.ispartof Physical Chemistry Chemical Physics es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Drug-DNA complexation as the key factor in photosensitized thymine dimerization es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1039/c6cp08485k es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CTQ2014-54729-C2-2-P/ES/DISEÑO DE NUEVAS PRODROGAS ANTICANCERIGENAS FOTOACTIVABLES/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//SEV-2012-0267/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CTQ2015-70164-P/ES/LESIONES DEL ADN COMO FOTOSENSIBILIZADORES INTRINSECOS - CONCEPTO DE CABALLO DE TROYA/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Cuquerella Alabort, MC.; Lhiaubet, VL.; Miranda Alonso, MÁ.; Bosca Mayans, F. (2017). Drug-DNA complexation as the key factor in photosensitized thymine dimerization. Physical Chemistry Chemical Physics. 19(7):4951-4955. https://doi.org/10.1039/c6cp08485k es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1039/c6cp08485k es_ES
dc.description.upvformatpinicio 4951 es_ES
dc.description.upvformatpfin 4955 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 19 es_ES
dc.description.issue 7 es_ES
dc.relation.pasarela S\325620 es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Generalitat Valenciana es_ES
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