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dc.contributor.author | Martínez, Maria-Luisa![]() |
es_ES |
dc.contributor.author | Escario, Eduardo![]() |
es_ES |
dc.contributor.author | Poblet, Enrique![]() |
es_ES |
dc.contributor.author | Sánchez, David![]() |
es_ES |
dc.contributor.author | Buchón Moragues, Fernando Francisco![]() |
es_ES |
dc.contributor.author | Izeta, Ander![]() |
es_ES |
dc.contributor.author | Jimenez, Francisco![]() |
es_ES |
dc.date.accessioned | 2018-10-31T05:33:41Z | |
dc.date.available | 2018-10-31T05:33:41Z | |
dc.date.issued | 2016 | es_ES |
dc.identifier.issn | 0190-9622 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/111607 | |
dc.description.abstract | [EN] Background: A prominent role of hair follicle-derived cells in epidermal wound closure is now well established but clinical translation of basic research findings is scarce. Although skin punch grafts have been used as a therapeutic intervention to improve healing of chronic leg ulcers, they are normally harvested from nonhairy areas, thus not taking advantage of the reported role of the hair follicle as a wound-healing promoter. Objective: We sought to substantiate the role of hair follicles in venous leg ulcer healing by transplanting hair follicle-containing versus nonhairy punch grafts. Methods: This was a randomized controlled trial with intraindividual comparison of hair follicle scalp grafts and nonhairy skin grafts transplanted in parallel into 2 halves of the same ulcer. Results: Ulcer healing measured as the average percentage reduction 18 weeks postintervention was significantly increased (P = .002) in the hair follicle group with a 75.15% (SD 23.03) ulcer area reduction compared with 33.07% (SD 46.17) in the control group (nonhairy grafts). Limitations: Sample size was small (n = 12). Conclusion: Autologous transplantation of terminal hair follicles by scalp punch grafts induces better healing than punch grafts harvested from nonhairy areas. Hair punch grafting is a minimally invasive surgical procedure that appears to be effective as a therapeutic tool for chronic venous leg ulcers. | es_ES |
dc.description.sponsorship | Partially funded by grants from the Hospital General Universitario de Albacete. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | Journal of the American Academy of Dermatology | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Follicular unit | es_ES |
dc.subject | Hair follicle stem cells | es_ES |
dc.subject | Hair transplantation | es_ES |
dc.subject | Punch grafting | es_ES |
dc.subject | Skin grafting | es_ES |
dc.subject | Venous leg ulcer | es_ES |
dc.subject | Wound healing | es_ES |
dc.subject.classification | INGENIERIA CARTOGRAFICA, GEODESIA Y FOTOGRAMETRIA | es_ES |
dc.title | Hair follicle-containing punch grafts accelerate chronic ulcer healing: A randomized controlled trial | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.jaad.2016.02.1161 | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Ingeniería Cartográfica Geodesia y Fotogrametría - Departament d'Enginyeria Cartogràfica, Geodèsia i Fotogrametria | es_ES |
dc.description.bibliographicCitation | Martínez, M.; Escario, E.; Poblet, E.; Sánchez, D.; Buchón Moragues, FF.; Izeta, A.; Jimenez, F. (2016). Hair follicle-containing punch grafts accelerate chronic ulcer healing: A randomized controlled trial. Journal of the American Academy of Dermatology. 75(5):1007-1014. https://doi.org/10.1016/j.jaad.2016.02.1161 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.jaad.2016.02.1161 | es_ES |
dc.description.upvformatpinicio | 1007 | es_ES |
dc.description.upvformatpfin | 1014 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 75 | es_ES |
dc.description.issue | 5 | es_ES |
dc.relation.pasarela | S\346841 | es_ES |
dc.contributor.funder | Complejo Hospitalario Universitario de Albacete |