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Direct Electron Transfer to Cytochrome c Induced by a Conducting Polymer

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Direct Electron Transfer to Cytochrome c Induced by a Conducting Polymer

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dc.contributor.author López-Bernabeu, Sara es_ES
dc.contributor.author Huerta, Francisco es_ES
dc.contributor.author Morallón, Emilia es_ES
dc.contributor.author Montilla-Jiménez, Francisco es_ES
dc.date.accessioned 2018-11-08T05:33:20Z
dc.date.available 2018-11-08T05:33:20Z
dc.date.issued 2017 es_ES
dc.identifier.issn 1932-7447 es_ES
dc.identifier.uri http://hdl.handle.net/10251/112084
dc.description.abstract [EN] The direct electron transfer (DET) to redox proteins has become a central topic in the development of biotechnological devices. The present work explores the mechanisms of the direct electrochemistry between cytochrome c (cyt c) and a conducting polymer, poly(3,4ethylenedioxythiophene) doped with poly(styrenesulfonate) (PEDOT PSS). This polymer has been electrosynthesized from its monomers in aqueous solution on gold electrodes, and its capabilities for DET to cyt c have been examined by electrochemical and spectroelectrochemical methods. The polymer was electrodeposited with controlled thickness, and we determined that the electron transfer rate constant for cyt c oxidation was about 2 orders of magnitude higher than those obtained at conventional electrodes. Spectroelectrochemical measurements allowed us to evaluate the redox state of the polymer as a function of the potential and, in addition, the observation of intrinsic cyt c redox activity upon electron transfer from the conducting polymer. During the oxidation process of this protein, lysine residues placed near the heme crevice interact electrostatically with the anionic polyelectrolyte PSS. This interaction favors the orientation of the heme group toward the chains of the PEDOT backbone, which is eventually responsible for the electron transfer to the protein. es_ES
dc.description.sponsorship We gratefully acknowledge financial support from the Spanish Ministerio de Economia y Competitividad and FEDER funds (MAT2016-76595-R) and the Generalitat Valenciana (PROM-ET02013/038). es_ES
dc.language Inglés es_ES
dc.publisher American Chemical Society es_ES
dc.relation.ispartof The Journal of Physical Chemistry C es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject.classification QUIMICA FISICA es_ES
dc.title Direct Electron Transfer to Cytochrome c Induced by a Conducting Polymer es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1021/acs.jpcc.7b05204 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2016-76595-R/ES/NUEVAS ESTRATEGIAS DE FUNCIONALIZACION ELECTROQUIMICA DE MATERIALES CARBONOSOS NANOESTRUCTURADOS PARA LA REDUCCION DE OXIGENO Y BIOSENSORES/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2013%2F038/ES/Desarrollo de nuevos electrodos y procesos químicos sostenibles para la detección de analitos obtenidos por microextracción líquido-líquido/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Textil y Papelera - Departament d'Enginyeria Tèxtil i Paperera es_ES
dc.description.bibliographicCitation López-Bernabeu, S.; Huerta, F.; Morallón, E.; Montilla-Jiménez, F. (2017). Direct Electron Transfer to Cytochrome c Induced by a Conducting Polymer. The Journal of Physical Chemistry C. 121(29):15870-15879. https://doi.org/10.1021/acs.jpcc.7b05204 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1021/acs.jpcc.7b05204 es_ES
dc.description.upvformatpinicio 15870 es_ES
dc.description.upvformatpfin 15879 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 121 es_ES
dc.description.issue 29 es_ES
dc.relation.pasarela S\366484 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Economía y Competitividad


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