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dc.contributor.author | Caddeo, C. | es_ES |
dc.contributor.author | Manca, M.L. | es_ES |
dc.contributor.author | Matos, Maria | es_ES |
dc.contributor.author | Gutierrez, Gemma | es_ES |
dc.contributor.author | Díez-Sales, Octavio | es_ES |
dc.contributor.author | Esteban Peris, J. | es_ES |
dc.contributor.author | Usach, Iris | es_ES |
dc.contributor.author | Fernandez-Busquets, X. | es_ES |
dc.contributor.author | Fadda, A.M. | es_ES |
dc.contributor.author | Manconi, Maria | es_ES |
dc.date.accessioned | 2018-11-14T21:03:39Z | |
dc.date.available | 2018-11-14T21:03:39Z | |
dc.date.issued | 2017 | es_ES |
dc.identifier.issn | 1549-9634 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/112508 | |
dc.description.abstract | [EN] Resveratrol and gallic acid, a lipophilic and a hydrophilic phenol, were co-loaded in innovative, biocompatible nanovesicles conceived for ensuring the protection of the skin from oxidative-and inflammatory-related affections. The basic vesicles, liposomes and glycerosomes, were produced by a simple, one-step method involving the dispersion of phospholipid and phenols in water or water/glycerol blend, respectively. Liposomes and glycerosomes were modified by the addition of poloxamer, a stabilizer and viscosity enhancer, thus obtaining viscous or semisolid dispersions of structured vesicles. The vesicles were spherical, unilamellar and small in size (similar to 70 nm in diameter). The superior ability of the poloxamer-structured vesicles to promote the accumulation of both phenols in the skin was demonstrated, as well as their low toxicity and great ability to protect fibroblasts from chemically-induced oxidative damage. The in vivo administration of the vesicular phenols on TPA (phorbol ester)-exposed skin led to a significant reduction of oedema and leukocyte infiltration. (C) 2017 Elsevier Inc. All rights reserved. | es_ES |
dc.description.sponsorship | This work was partially supported by grants BIO2014-52872-R (Ministerio de Economia y Competitividad, Spain), which included FEDER funds, and 2014-SGR-938 (Generalitat de Catalunya, Spain). | |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | Nanomedicine Nanotechnology Biology and Medicine | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Phospholipid vesicle | es_ES |
dc.subject | Phenol | es_ES |
dc.subject | Poloxamer | es_ES |
dc.subject | Fibroblasts | es_ES |
dc.subject | Mice | es_ES |
dc.subject | Skin inflammation | es_ES |
dc.title | Functional response of novel bioprotective poloxamer-structured vesicles on inflamed skin | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.nano.2016.12.017 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//BIO2014-52872-R/ES/INGENIERIA DE NANOVECTORES PARA LA LIBERACION DE FARMACOS ANTIMALARICOS A FASES DE TRANSMISION DE PLASMODIUM/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/Generalitat de Catalunya//2014 SGR 938/ | |
dc.rights.accessRights | Cerrado | es_ES |
dc.description.bibliographicCitation | Caddeo, C.; Manca, M.; Matos, M.; Gutierrez, G.; Díez-Sales, O.; Esteban Peris, J.; Usach, I.... (2017). Functional response of novel bioprotective poloxamer-structured vesicles on inflamed skin. Nanomedicine Nanotechnology Biology and Medicine. 13(3):1127-1136. https://doi.org/10.1016/j.nano.2016.12.017 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.nano.2016.12.017 | es_ES |
dc.description.upvformatpinicio | 1127 | es_ES |
dc.description.upvformatpfin | 1136 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 13 | es_ES |
dc.description.issue | 3 | es_ES |
dc.identifier.pmid | 28064008 | |
dc.relation.pasarela | S\352719 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | |
dc.contributor.funder | Generalitat Valenciana | |
dc.contributor.funder | Generalitat de Catalunya | es_ES |