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Determination of the chemical warfare agents Sarin, Soman and Tabun in natural waters employing fluorescent hybrid silica materials

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Determination of the chemical warfare agents Sarin, Soman and Tabun in natural waters employing fluorescent hybrid silica materials

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dc.contributor.author Climent, E. es_ES
dc.contributor.author Biyikal, Mustafa es_ES
dc.contributor.author Gawlitza, K. es_ES
dc.contributor.author Dropa, T. es_ES
dc.contributor.author Urban, M. es_ES
dc.contributor.author Costero, Ana M. es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Rurack, K. es_ES
dc.date.accessioned 2018-11-14T21:03:56Z
dc.date.available 2018-11-14T21:03:56Z
dc.date.issued 2017 es_ES
dc.identifier.issn 0925-4005 es_ES
dc.identifier.uri http://hdl.handle.net/10251/112513
dc.description.abstract [EN] A novel mesoporous silica material containing boron-dipyrromethene (BODIPY) moieties (I) is employed for the detection of nerve agent simulants (NASs) and the organophosphate nerve or chemical warfare agents (CWAs) Sarin (GB), Soman (GD), and Tabun (GA) in aqueous environments. The reactive BODIPY dye with an optimum positioned hydroxyl group undergoes acylation reactions with phosph(on)ate substrates, yielding a bicyclic ring. Due to aggregation of the dyes in water, the sensitivity of the free dye in solution is very low. Only after immobilization of the BODIPY moieties into the silica substrates is aggregation inhibited and a sensitive determination of the NASs diethyl cyanophosphonate (DCNP), diethyl chlorophosphate (DCP) and diisopropyl fluorophosphate (DFP) possible. The signaling mode is a strong quenching of the fluorescence, reaching LODs in the pM range. The best performing hybrid material was singled out from a library of hybrid silicas varying in morphology and surface functionalization. The response to actual CWAs such as GB, GD, and GA has also been tested, offering similar behavior as for the simulants. The proposed reaction mechanism has been verified by investigation of other model materials, containing for instance BODIPY moieties without an optimum hydroxyl group (III) or a BODIPY dye with an all-aliphatic counterpart (IV). The latter can only form a monocyclic reaction product, showing much less reactivity as I. Assays with other possible competitors have been additionally carried out, showing favorably low cross-reactivities. Finally, the determination of NASs in several natural waters has been demonstrated. (C) 2017 Elsevier B.V. All rights reserved. es_ES
dc.description.sponsorship Financial support from the Alexander von Humboldt Foundation, Germany's Federal Ministry for Economic Affairs and Energy, the Generalitat Valenciana (Project PROMETEOII/2014/047), the Spanish Government and European FEDER funds (Project MAT2015-64139-C4) is gratefully acknowledged. We thank S. Selve (Technical University Berlin) for TEM images, A. Zehl (Humboldt University Berlin) for elemental analysis, D. Pfeifer and C. Jager (BAM, Div. 1.3) for NMR support, A. Zimathies (BAM, Div. 1.3) for N2 adsorption/desorption measurements and T. Fischer (BAM, Div. 1.9) for support with the fluorescence decay measurements.
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation info:eu-repo/grantAgreement/MINECO//MAT2015-64139-C4-4-R/ES/QUIMIOSENSORES CROMOGENICOS Y FLUOROGENICOS PARA LA DETECCION DE NEUROTRASMISORES/ es_ES
dc.relation info:eu-repo/grantAgreement/MINECO//MAT2015-64139-C4-1-R/ES/NANOMATERIALES INTELIGENTES, SONDAS Y DISPOSITIVOS PARA EL DESARROLLO INTEGRADO DE NUEVAS HERRAMIENTAS APLICADAS AL CAMPO BIOMEDICO/ es_ES
dc.relation GV/PROMETEOII/2014/047 es_ES
dc.relation.ispartof Sensors and Actuators B Chemical es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Nerve agent simulants es_ES
dc.subject Mesoporous silica materials es_ES
dc.subject Fluorescence detection es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title Determination of the chemical warfare agents Sarin, Soman and Tabun in natural waters employing fluorescent hybrid silica materials es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.snb.2017.02.115 es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.description.bibliographicCitation Climent, E.; Biyikal, M.; Gawlitza, K.; Dropa, T.; Urban, M.; Costero, AM.; Martínez-Máñez, R.... (2017). Determination of the chemical warfare agents Sarin, Soman and Tabun in natural waters employing fluorescent hybrid silica materials. Sensors and Actuators B Chemical. 246:1056-1065. https://doi.org/10.1016/j.snb.2017.02.115 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1016/j.snb.2017.02.115 es_ES
dc.description.upvformatpinicio 1056 es_ES
dc.description.upvformatpfin 1065 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 246 es_ES
dc.relation.pasarela S\336311 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Ministerio de Economía, Industria y Competitividad es_ES


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