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A clinically-oriented computer model for radiofrequency ablation of hepatic tissue with internally cooled wet electrode

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A clinically-oriented computer model for radiofrequency ablation of hepatic tissue with internally cooled wet electrode

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dc.contributor.author Ewertowska, Elzbieta es_ES
dc.contributor.author Quesada-Diez, Rita es_ES
dc.contributor.author Radosevic, A. es_ES
dc.contributor.author Andaluz, Anna es_ES
dc.contributor.author Moll, Xavier es_ES
dc.contributor.author García Arnás, F. es_ES
dc.contributor.author Berjano, Enrique es_ES
dc.contributor.author Burdío Pinilla, Fernando es_ES
dc.contributor.author Trujillo Guillen, Macarena es_ES
dc.date.accessioned 2019-03-01T13:33:57Z
dc.date.available 2019-03-01T13:33:57Z
dc.date.issued 2019 es_ES
dc.identifier.issn 0265-6736 es_ES
dc.identifier.uri http://hdl.handle.net/10251/117537
dc.description.abstract [EN] Purpose: To improve the computer modelling of radiofrequency ablation (RFA) by internally cooled wet (ICW) electrodes with added clinically oriented features. Methods: An improved RFA computer model by ICW electrode included: (1) a realistic spatial distribution of the infused saline, and (2) different domains to distinguish between healthy tissue, saline-infused tumour, and non-infused tumour, under the assumption that infused saline is retained within the tumour boundary. A realistic saline spatial distribution was obtained from an in vivo pig liver study. The computer results were analysed in terms of impedance evolution and coagulation zone (CZ) size, and were compared to the results of clinical trials conducted on 17 patients with the same ICW electrode. Results: The new features added to the model provided computer results that matched well with the clinical results. No roll-offs occurred during the 4-min ablation. CZ transversal diameter (4.10 +/- 0.19 cm) was similar to the computed diameter (4.16 cm). Including the tumour and saline infusion in the model involved (1) a reduction of the initial impedance by 10 - 20 ohm, (2) a delay in roll-off of 20 s and 70 - 100 s, respectively, and (3) 18 - 31% and 22 - 36% larger CZ size, respectively. The saline spatial distribution geometry was also seen to affect roll-off delay and CZ size. Conclusions: Using a three-compartment model and a realistic saline spatial distribution notably improves the match with the outcome of the clinical trials. es_ES
dc.description.sponsorship This work was supported by the Spanish Ministerio de Economia, Industria y Competitividad under the "Plan Estatal de Investigacion, Desarrollo e Innovacion Orientada a los Retos de la Sociedad" Grant TEC2014-52383-C3-R (TEC2014-52383-C3-1-R and TEC2014-52383-C3-3-R). Elzbieta Ewertowska has a Predoctoral Grant (BES-2015-073285) from the Ministry of Economy, Industry and Competitiveness (Government of Spain).
dc.language Inglés es_ES
dc.publisher Taylor & Francis es_ES
dc.relation MINECO/BES-2015-073285 es_ES
dc.relation MINECO/TEC2014-52383-C3-1-R-AR es_ES
dc.relation.ispartof International Journal of Hyperthermia es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Internally cooled wet electrode es_ES
dc.subject Radiofrequency ablation es_ES
dc.subject Computer model es_ES
dc.subject Rehydration es_ES
dc.subject Saline distribution es_ES
dc.subject.classification MATEMATICA APLICADA es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title A clinically-oriented computer model for radiofrequency ablation of hepatic tissue with internally cooled wet electrode es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1080/02656736.2018.1489071 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada es_ES
dc.description.bibliographicCitation Ewertowska, E.; Quesada-Diez, R.; Radosevic, A.; Andaluz, A.; Moll, X.; García Arnás, F.; Berjano, E.... (2019). A clinically-oriented computer model for radiofrequency ablation of hepatic tissue with internally cooled wet electrode. International Journal of Hyperthermia. 35(1):194-204. https://doi.org/10.1080/02656736.2018.1489071 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1080/02656736.2018.1489071 es_ES
dc.description.upvformatpinicio 194 es_ES
dc.description.upvformatpfin 204 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 35 es_ES
dc.description.issue 1 es_ES
dc.identifier.pmid 30293464
dc.relation.pasarela 369827 es_ES
dc.contributor.funder Ministerio de Economía, Industria y Competitividad es_ES


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