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In Silico QT and APD Prolongation Assay for Early Screening of Drug-Induced Proarrhythmic Risk

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In Silico QT and APD Prolongation Assay for Early Screening of Drug-Induced Proarrhythmic Risk

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Romero Pérez, L.; Cano-García, J.; Gomis-Tena Dolz, J.; Trenor Gomis, BA.; Sanz, F.; Pastor, M.; Saiz Rodríguez, FJ. (2018). In Silico QT and APD Prolongation Assay for Early Screening of Drug-Induced Proarrhythmic Risk. Journal of Chemical Information and Modeling. 58(4):867-878. https://doi.org/10.1021/acs.jcim.7b00440

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/119060

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Title: In Silico QT and APD Prolongation Assay for Early Screening of Drug-Induced Proarrhythmic Risk
Author: Romero Pérez, Lucia Cano-García, Jordi Gomis-Tena Dolz, Julio Trenor Gomis, Beatriz Ana Sanz, Ferran Pastor, Manuel Saiz Rodríguez, Francisco Javier
UPV Unit: Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica
Issued date:
Abstract:
[EN] Drug-induced proarrhythmicity is a major concern for regulators and pharmaceutical companies. For novel drug candidates, the standard assessment involves the evaluation of the potassium hERG channels block and the in ...[+]
Copyrigths: Reserva de todos los derechos
Source:
Journal of Chemical Information and Modeling. (issn: 1549-9596 )
DOI: 10.1021/acs.jcim.7b00440
Publisher:
American Chemical Society
Publisher version: http://doi.org/10.1021/acs.jcim.7b00440
Project ID:
info:eu-repo/grantAgreement/EC/FP7/115002/EU
IMI JOINT UNDERTAKING/115002
MINECODPI2015-69125-R
GV/PROMETEO/2016/088
Thanks:
L.R, J.C., J.G., B.T., J.S.: This work was partially supported by the Direccion General de Politica Cientifica de la Generalitat Valenciana (PROMETEU2016/088) as well as Ministerio de Economia y Competitividad and Fondo ...[+]
Type: Artículo

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