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Extracellular vesicles: A new therapeutic strategy for joint conditions

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Extracellular vesicles: A new therapeutic strategy for joint conditions

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dc.contributor.author Tofiño-Vian, Miguel es_ES
dc.contributor.author Guillen Salazar, Mª Isabel es_ES
dc.contributor.author Alcaraz Tormo, Mª Jose es_ES
dc.date.accessioned 2019-05-06T20:02:03Z
dc.date.available 2019-05-06T20:02:03Z
dc.date.issued 2018 es_ES
dc.identifier.issn 0006-2952 es_ES
dc.identifier.uri http://hdl.handle.net/10251/119995
dc.description.abstract [EN] Extracellular vesicles (EVs) are attracting increasing interest since they might represent a more convenient therapeutic tool with respect to their cells of origin. In the last years much time and effort have been expended to determine the biological properties of EVs from mesenchymal stem cells (MSCs) and other sources. The immunoregulatory, anti-inflammatory and regenerative properties of MSC EVs have been demonstrated in in vitro studies and animal models of rheumatoid arthritis or osteoarthritis. This cell-free approach has been proposed as a possible better alternative to MSC therapy in autoimmune conditions and tissue regeneration. In addition, EVs show great potential as biomarkers of disease or delivery systems for active molecules. The standardization of isolation and characterization methods is a key step for the development of EV research. A better understanding of EV mechanisms of action and efficacy is required to establish the potential therapeutic applications of this new approach in joint conditions. es_ES
dc.description.sponsorship This work has been funded by grants SAF2013-48724R (MINECO,FEDER, Spain) and PROMETEOII/2014/071 (Generalitat Valenciana, Spain).
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Biochemical Pharmacology es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Extracellular vesicles es_ES
dc.subject Mesenchymal stem cells es_ES
dc.subject Inflammation es_ES
dc.subject Immunomodulation es_ES
dc.subject Rheumatoid arthritis es_ES
dc.subject Osteoarthritis es_ES
dc.title Extracellular vesicles: A new therapeutic strategy for joint conditions es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.bcp.2018.02.004 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2014%2F071/ES/Estrategias de protección frente a procesos inflamatorios y degenerativos/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//SAF2013-48724-R/ES/MECANISMOS CELULARES REGULADORES DE LA RESPUESTA INFLAMATORIA EN PATOLOGIAS ARTICULARES CRONICAS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.date.embargoEndDate 2019-07-01 es_ES
dc.description.bibliographicCitation Tofiño-Vian, M.; Guillen Salazar, MI.; Alcaraz Tormo, MJ. (2018). Extracellular vesicles: A new therapeutic strategy for joint conditions. Biochemical Pharmacology. 153:134-146. https://doi.org/10.1016/j.bcp.2018.02.004 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1016/j.bcp.2018.02.004 es_ES
dc.description.upvformatpinicio 134 es_ES
dc.description.upvformatpfin 146 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 153 es_ES
dc.identifier.pmid 29427625
dc.relation.pasarela S\378191 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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