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Bioprospecting for antagonistic Penicillium strains as a resource of new antitumoral compounds

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Bioprospecting for antagonistic Penicillium strains as a resource of new antitumoral compounds

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dc.contributor.author Nicoletti, Rosario es_ES
dc.contributor.author Buommino, Elisabetta es_ES
dc.contributor.author De Filippis, Anna es_ES
dc.contributor.author López-Gresa, María Pilar es_ES
dc.contributor.author Manzo, Emiliano es_ES
dc.contributor.author Carella, Angela es_ES
dc.contributor.author Petrazzuolo, Marcella es_ES
dc.contributor.author Tufano, Maria Antonietta es_ES
dc.date.accessioned 2019-05-06T20:02:12Z
dc.date.available 2019-05-06T20:02:12Z
dc.date.issued 2007 es_ES
dc.identifier.issn 0959-3993 es_ES
dc.identifier.uri http://hdl.handle.net/10251/119997
dc.description.abstract [EN] Microorganisms are increasingly exploited as a source of new pharmaceuticals. Soil fungi are particularly promising to this regard since their biocenotic competitiveness is often based on the production of antibiotics and other inhibitory substances. About 15 Penicillium strains possessing some extent of antifungal ability were evaluated as a possible source of antitumor products based on the antiproliferative and pro-apoptotic effects of their culture extracts on human tumor cell lines. About 12 strains showed some extent of antitumor properties that in several cases corresponded to the effect of the extrolites purified from the culture extracts themselves. The study showed that a quick screening of fungal isolates can be operated by assaying their fungal extracts on tumor cells directly, with the ensuing advantage of restricting the work required for the characterization of the bioactive compounds to a reduced number of promising strains. es_ES
dc.language Inglés es_ES
dc.publisher Springer-Verlag es_ES
dc.relation.ispartof World Journal of Microbiology and Biotechnology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Apoptosis es_ES
dc.subject Cell proliferation es_ES
dc.subject Cytostatic activity es_ES
dc.subject DNA laddering es_ES
dc.subject Extrolites es_ES
dc.subject Fungal extracts es_ES
dc.subject.classification BIOQUIMICA Y BIOLOGIA MOLECULAR es_ES
dc.title Bioprospecting for antagonistic Penicillium strains as a resource of new antitumoral compounds es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s11274-007-9455-y es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.description.bibliographicCitation Nicoletti, R.; Buommino, E.; De Filippis, A.; López-Gresa, MP.; Manzo, E.; Carella, A.; Petrazzuolo, M.... (2007). Bioprospecting for antagonistic Penicillium strains as a resource of new antitumoral compounds. World Journal of Microbiology and Biotechnology. 24(2):189-195. https://doi.org/10.1007/s11274-007-9455-y es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1007/s11274-007-9455-y es_ES
dc.description.upvformatpinicio 189 es_ES
dc.description.upvformatpfin 195 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 24 es_ES
dc.description.issue 2 es_ES
dc.relation.pasarela S\32848 es_ES
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