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Antibiotic residues in milk and cheeses after the off-label use of macrolides in dairy goats

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Antibiotic residues in milk and cheeses after the off-label use of macrolides in dairy goats

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dc.contributor.author Quintanilla-Vázquez, Paloma Galicia es_ES
dc.contributor.author Beltrán Martínez, Mª Carmen es_ES
dc.contributor.author Peris Palau, Bernardo es_ES
dc.contributor.author Rodríguez Garcia, Martín es_ES
dc.contributor.author Molina Pons, Mª Pilar es_ES
dc.date.accessioned 2019-05-31T20:43:59Z
dc.date.available 2019-05-31T20:43:59Z
dc.date.issued 2018 es_ES
dc.identifier.issn 0921-4488 es_ES
dc.identifier.uri http://hdl.handle.net/10251/121373
dc.description.abstract [EN] The limited availability of drugs registered for dairy goats makes veterinarians prescribe off-label treatments with a legally established minimum safety period of seven days. The aim of this work was to verify if the exceptional use of macrolide antibiotics in dairy goats generates residues in milk and cheeses within that period. Hence, three macrolide drugs (erythromycin, tylosin and spiramycin) were administred in an in vivo experiment in dairy goats. Ripened cheeses were made from bulk milk obtained before drug administration, 24¿h after treatment, and at the end of the recommended withdrawal period. Residual amounts of erythromycin (234.9¿±¿52.7¿¿g/kg), tylosin (198.7¿±¿57.8¿¿g/kg) and spiramycin (1539.8¿±¿469.4¿¿g/kg), widely exceeding their legal maximum residue limits (MRLs) established, were detected in milk collected 24¿h after treatment, making the cheese production in most cases impossible. After the seven-day period, only spiramycin was detected in goat¿s milk (79.6¿±¿19.2¿¿g/kg) although no antibiotic residues were found in the cheeses. A withdrawal time of seven days seems suitable to guarantee milk safety after the administration of erythromycin and tylosin without any negative effects neither on the milk nor on the and cheese properties. However, given the rapid elimination of these substances, a shorter withdrawal period might be considered. For spiramycin, persisting in milk for a longer period, further studies on its pharmacokinetics in dairy goats would be recommendable to avoid a potential risk to consumer health. es_ES
dc.description.sponsorship This work is part of the AGL-2013-45147-R funded by Ministerio de Ciencia e Innovacion (Madrid. Spain). The authors thank the 'Program of Support for Research and Development' (PAID-2014, UPV) for support P. Quintanilla PhD studies at Universitat Politecnica de Valencia. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Small Ruminant Research es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Antibiotics es_ES
dc.subject Macrolide es_ES
dc.subject Goat s milk es_ES
dc.subject Goat cheese es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.title Antibiotic residues in milk and cheeses after the off-label use of macrolides in dairy goats es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.smallrumres.2018.08.008 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//AGL2013-45147-R/ES/TRAZABILIDAD DE LA PRESENCIA DE ANTIBIOTICOS EN LECHE, QUESO Y LACTOSUERO DE CABRA/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.description.bibliographicCitation Quintanilla-Vázquez, PG.; Beltrán Martínez, MC.; Peris Palau, B.; Rodríguez Garcia, M.; Molina Pons, MP. (2018). Antibiotic residues in milk and cheeses after the off-label use of macrolides in dairy goats. Small Ruminant Research. 167:55-60. https://doi.org/10.1016/j.smallrumres.2018.08.008 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1016/j.smallrumres.2018.08.008 es_ES
dc.description.upvformatpinicio 55 es_ES
dc.description.upvformatpfin 60 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 167 es_ES
dc.relation.pasarela S\370704 es_ES
dc.contributor.funder Ministerio de Economía y Empresa es_ES


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