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Endoluminal radiofrequency ablation of the main pancreatic duct is a secure and effective method to produce pancreatic atrophy and to achieve stump closure

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Endoluminal radiofrequency ablation of the main pancreatic duct is a secure and effective method to produce pancreatic atrophy and to achieve stump closure

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dc.contributor.author Andaluz, Anna es_ES
dc.contributor.author Ewertowska, Elzbieta es_ES
dc.contributor.author Moll, Xavier es_ES
dc.contributor.author Aguilar, Adrià es_ES
dc.contributor.author García, Félix es_ES
dc.contributor.author Fondevila, Dolors es_ES
dc.contributor.author Quesada, Rita es_ES
dc.contributor.author Berjano, Enrique es_ES
dc.contributor.author Grande, Luís es_ES
dc.contributor.author Burdío, Fernando es_ES
dc.date.accessioned 2019-07-05T20:02:33Z
dc.date.available 2019-07-05T20:02:33Z
dc.date.issued 2019 es_ES
dc.identifier.issn 2045-2322 es_ES
dc.identifier.uri http://hdl.handle.net/10251/123233
dc.description.abstract [EN] Radiofrequency energy has been used both experimentally and clinically to manage the pancreatic remnant after distal pancreatectomies. Our goal was to determine whether endoluminal radiofrequency (RF) ablation of the main pancreatic duct in large animals would be more efficient than glue occlusion as an exocrine pancreatic atrophy-inducing procedure. Thirty-four Landrace pigs were assigned to either the transpapilar (n = 16) or transection (n = 18) groups. The transection implied the pancreas neck was severed. In each of these groups the remaining distal pancreatic duct was occluded either by RF or by glue. In the transpapilar group complete atrophy was observed in all the RF cases, while atrophy was incomplete in all the members of the glue subgroup. The failure rate of the main pancreatic duct (usually expressed by a pseudocyst) in the transection groups was dramatically higher in the glue subgroup than the RF subgroups (9 out of 9 and 1 out of 9, respectively) and postoperative mortality occurred only in the glue subgroup (3 out of 9). These results show the superiority of endoluminal RF ablation over glue for main pancreatic duct occlusion, as seen by the degree of atrophy and fewer postoperative pancreatic fistulas. es_ES
dc.description.sponsorship This work was supported by the Spanish Ministerio de Economia, Industria y Competitividad under the "Plan Estatal de Investigacion, Desarrollo e Innovacion Orientada a los Retos de la Sociedad" Grant TEC2014-52383-C3-R (TEC2014-52383-C3-1-R and TEC2014-52383-C3-3-R). Elzbieta Ewertowska has a Predoctoral Grant (BES-2015-073285) from the Ministry of Economy, Industry and Competitiveness (Government of Spain). es_ES
dc.language Inglés es_ES
dc.publisher Nature Publishing Group es_ES
dc.relation.ispartof Scientific Reports es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Endoluminal radiofrequency ablation of the main pancreatic duct is a secure and effective method to produce pancreatic atrophy and to achieve stump closure es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1038/s41598-019-42411-7 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//BES-2015-073285/ES/BES-2015-073285/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//TEC2014-52383-C3-1-R/ES/TECNOLOGIAS BASADAS EN ENERGIA DE RADIOFRECUENCIA Y MICROONDAS PARA CIRUGIA DE MINIMA INVASION/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Andaluz, A.; Ewertowska, E.; Moll, X.; Aguilar, A.; García, F.; Fondevila, D.; Quesada, R.... (2019). Endoluminal radiofrequency ablation of the main pancreatic duct is a secure and effective method to produce pancreatic atrophy and to achieve stump closure. Scientific Reports. 9:1-10. https://doi.org/10.1038/s41598-019-42411-7 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1038/s41598-019-42411-7 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 10 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 9 es_ES
dc.relation.pasarela S\381741 es_ES
dc.contributor.funder Ministerio de Economía y Empresa es_ES
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