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Characterization of the effects of Atosiban on uterine electromyograms recorded in women with threatened preterm labor

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Characterization of the effects of Atosiban on uterine electromyograms recorded in women with threatened preterm labor

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dc.contributor.author Mas-Cabo, Javier es_ES
dc.contributor.author Prats-Boluda, Gema es_ES
dc.contributor.author Ye Lin, Yiyao es_ES
dc.contributor.author Alberola Rubio, José es_ES
dc.contributor.author Perales, Alfredo es_ES
dc.contributor.author Garcia-Casado, Javier es_ES
dc.date.accessioned 2019-07-14T20:02:26Z
dc.date.available 2019-07-14T20:02:26Z
dc.date.issued 2019 es_ES
dc.identifier.issn 1746-8094 es_ES
dc.identifier.uri http://hdl.handle.net/10251/123548
dc.description.abstract [EN] Although research studies using electrohysterography on women without tocolytic therapy have shown its potential for preterm birth diagnosis, tocolytics are usually administered in emergency rooms at the first sign of threatened preterm labor (TPL). Information on the uterine response during tocolytic treatment could prove useful for the development of tools able to predict true preterm deliveries under normal clinical conditions. The aim of this study was thus to analyze the effects of Atosiban on Electrohysterogram (EHG) parameters and to compare its effects on women who delivered preterm (WDP) and at term (WDT). Electrohysterograms recorded in different Atosiban therapy stages (before, during and after drug administration) on 40 WDT and 27 WDP were analyzed by computing linear, and non-linear EHG parameters. Results reveal that Atosiban does not greatly affect the EHG signal amplitude, but does modify its spectral content and reduces the energy associated with the fast wave high component in both WDP and WDT, with a faster response in the latter. EHG signal complexity remained constant in WDT, while it increased in WDP until it reached similar values to WDT during Atosiban treatment. The spectral and complexity parameters were able to separate (p < 0.05) WDT and WDP prior to and during tocolytic treatment and before and after treatment, respectively. The results pave the way for developing better and more reliable medical decision support systems based on EHG for preterm delivery prediction in TPL women in clinical scenarios. es_ES
dc.description.sponsorship This work received financial support from the Spanish Ministry of Economy and Competitiveness and the European Regional Development Fund (DPI2015-68397-R), VLC/Campus (UPV-FE-2018-B03) and by Conselleria de Educación, Investigación, Cultura y Deporte, Generalitat Valenciana (GV/2018/104).
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation UPV/UPV-FE-2018-B03 es_ES
dc.relation MINECO/DPI2015-68397-R es_ES
dc.relation GV/GV/2018/104 es_ES
dc.relation.ispartof Biomedical Signal Processing and Control es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Electrohysterogram es_ES
dc.subject Atosiban es_ES
dc.subject Excitability es_ES
dc.subject Complexity es_ES
dc.subject Preterm labor es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Characterization of the effects of Atosiban on uterine electromyograms recorded in women with threatened preterm labor es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.bspc.2019.04.001 es_ES
dc.rights.accessRights Embargado es_ES
dc.date.embargoEndDate 2021-07-01 es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Mas-Cabo, J.; Prats-Boluda, G.; Ye Lin, Y.; Alberola Rubio, J.; Perales, A.; Garcia-Casado, J. (2019). Characterization of the effects of Atosiban on uterine electromyograms recorded in women with threatened preterm labor. Biomedical Signal Processing and Control. 52:198-205. https://doi.org/10.1016/j.bspc.2019.04.001 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.bspc.2019.04.001 es_ES
dc.description.upvformatpinicio 198 es_ES
dc.description.upvformatpfin 205 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 52 es_ES
dc.relation.pasarela S\390726 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Economía y Empresa es_ES
dc.contributor.funder Universitat Politècnica de València es_ES


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