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Genetic parameters for birthweight environmental variability in mice

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Genetic parameters for birthweight environmental variability in mice

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dc.contributor.author Pun, A. es_ES
dc.contributor.author Cervantes, I. es_ES
dc.contributor.author Nieto, B. es_ES
dc.contributor.author Perez-Cabal, M.A. es_ES
dc.contributor.author Salgado, C. es_ES
dc.contributor.author Ibañez Escriche, Noelia es_ES
dc.contributor.author Gutiérrez, J.P. es_ES
dc.date.accessioned 2019-09-05T20:04:15Z
dc.date.available 2019-09-05T20:04:15Z
dc.date.issued 2013 es_ES
dc.identifier.issn 0931-2668 es_ES
dc.identifier.uri http://hdl.handle.net/10251/125097
dc.description.abstract [EN] Data from a divergent experiment for birthweight (BrW) environmental variability were used to estimate genetic parameters for BrW trait and its environmental variability by fitting both homoscedastic (HO) and heteroscedastic (HE) models. A total of 5475 records of BrW from animals born from inbred dams, and 7140 pedigree records were used. The heritability of BrW using the model HO was 0.27, with the litter effect much more important, 0.43. The model HE provided a genetic correlation between the trait and its environmental variability that was very high and negative, -0.97, and a high value for the additive genetic variance for environmental variability, suggesting an artefact in the model. The residual skewness was found to be essentially null. A model considering the genetic correlation null was also fitted, and used to obtain the breeding values for the selection process. Moreover, the trait was considered as maternal resulting in similar estimates under the model HO, but more reasonable for the genetic correlation between the trait and its environmental variability of 0.48 with a value of 0.25 for the additive genetic variance regarding environmental variability under the model HE. This led to the conclusion that environmental variability of BrW in mice must be selected via dams. Estimated parameters in a reduced dataset without inbred animals did not substantially change this conclusion. es_ES
dc.description.sponsorship This study was partially funded by a grant from the Spanish Government (AGL2008-00794). The authors want to acknowledge the important contributions made by Loys Bodin.
dc.language Inglés es_ES
dc.publisher Blackwell Publishing es_ES
dc.relation MEC/AGL2008-00794
dc.relation.ispartof Journal of Animal Breeding and Genetics es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Birthweight es_ES
dc.subject Canalization es_ES
dc.subject Environmental variability es_ES
dc.subject Genetic correlation es_ES
dc.subject Mice es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.title Genetic parameters for birthweight environmental variability in mice es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1111/jbg.12021 es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.description.bibliographicCitation Pun, A.; Cervantes, I.; Nieto, B.; Perez-Cabal, M.; Salgado, C.; Ibañez Escriche, N.; Gutiérrez, J. (2013). Genetic parameters for birthweight environmental variability in mice. Journal of Animal Breeding and Genetics. 130(5):404-414. https://doi.org/10.1111/jbg.12021 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1111/jbg.12021 es_ES
dc.description.upvformatpinicio 404 es_ES
dc.description.upvformatpfin 414 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 130 es_ES
dc.description.issue 5 es_ES
dc.identifier.pmid 24074177
dc.relation.pasarela S\343537 es_ES
dc.contributor.funder Ministerio de Educación y Ciencia


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