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Effects of the inhibition of late sodium current by GS967 on stretch-induced changes in cardiac electrophysiology

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Effects of the inhibition of late sodium current by GS967 on stretch-induced changes in cardiac electrophysiology

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Canto Serrano, ID.; Santamaría, L.; Genovés, P.; Such-Miquel, L.; Arias-Mutis, ÓJ.; Zarzoso Muñoz, M.; Soler, C.... (2018). Effects of the inhibition of late sodium current by GS967 on stretch-induced changes in cardiac electrophysiology. Cardiovascular Drugs and Therapy. 32(5):413-425. https://doi.org/10.1007/s10557-018-6822-x

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/125110

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Title: Effects of the inhibition of late sodium current by GS967 on stretch-induced changes in cardiac electrophysiology
Author: Canto Serrano, Irene Del Santamaría, L. Genovés, P. Such-Miquel, Luis Arias-Mutis, Óscar Julián Zarzoso Muñoz, Manuel Soler, C. Parra-Giraldo, G. Tormos Ferrando, Álvaro Alberola, Antonio Such Belenguer, Luis Chorro, F.J.
UPV Unit: Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica
Issued date:
Abstract:
[EN] PurposeMechanical stretch increases sodium and calcium entry into myocytes and activates the late sodium current. GS967, a triazolopyridine derivative, is a sodium channel blocker with preferential effects on the late ...[+]
Subjects: Mechanoelectric feedback , Myocardial stretch , Late sodium current , GS967 , Ventricular fibrillation , Activation mapping of arrhythmias
Copyrigths: Cerrado
Source:
Cardiovascular Drugs and Therapy. (issn: 0920-3206 )
DOI: 10.1007/s10557-018-6822-x
Publisher:
Springer-Verlag
Publisher version: https://doi.org/10.1007/s10557-018-6822-x
Project ID:
GV/PROMETEOII/2014/037
ISCIII/CB16/11/00486
ISCIII/PI12/00407
ISCIII/PI15/01408
ISCIII/PIE15/00013
Thanks:
This work was supported by the Spanish Ministry of Economy and Competiveness (Carlos III Health Institute)/European Regional Development Fund (FEDER) (Grants FIS PI12/00407, PI15/01408, PIE15/00013, CB16/11/00486) and by ...[+]
Type: Artículo

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