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Effects of S-Nitrosoglutathione on Electrophysiological Manifestations of Mechanoelectric Feedback

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Effects of S-Nitrosoglutathione on Electrophysiological Manifestations of Mechanoelectric Feedback

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dc.contributor.author Such-Miquel, Luis es_ES
dc.contributor.author Canto Serrano, Irene Del es_ES
dc.contributor.author Zarzoso Muñoz, Manuel es_ES
dc.contributor.author Brines-Ferrando, L. es_ES
dc.contributor.author Soler, C. es_ES
dc.contributor.author Parra-Giraldo, G. es_ES
dc.contributor.author Guill Ibáñez, Antonio es_ES
dc.contributor.author Alberola, Antonio es_ES
dc.contributor.author Such Belenguer, Luis es_ES
dc.contributor.author Chorro, F.J. es_ES
dc.date.accessioned 2019-09-05T20:05:35Z
dc.date.available 2019-09-05T20:05:35Z
dc.date.issued 2018 es_ES
dc.identifier.issn 1530-7905 es_ES
dc.identifier.uri http://hdl.handle.net/10251/125131
dc.description.abstract [EN] Electromechanical coupling studies have described the intervention of nitric oxide and S-nitrosylation processes in Ca2+ release induced by stretch, with heterogeneous findings. On the other hand, ion channel function activated by stretch is influenced by nitric oxide, and concentration-dependent biphasic effects upon several cellular functions have been described. The present study uses isolated and perfused rabbit hearts to investigate the changes in mechanoelectric feedback produced by two different concentrations of the nitric oxide carrier S-nitrosoglutathione. Epicardial multielectrodes were used to record myocardial activation at baseline and during and after left ventricular free wall stretch using an intraventricular device. Three experimental series were studied: (a) control (n=10); (b) S-nitrosoglutathione 10 mu M (n=11); and (c) S-nitrosoglutathione 50 mu M (n=11). The changes in ventricular fibrillation (VF) pattern induced by stretch were analyzed and compared. S-nitrosoglutathione 10 mu M did not modify VF at baseline, but attenuated acceleration of the arrhythmia (15.6 +/- 1.7 vs. 21.3 +/- 3.8Hz; p<0.0001) and reduction of percentile 5 of the activation intervals (42 +/- 3 vs. 38 +/- 4ms; p<0.05) induced by stretch. In contrast, at baseline using the 50 mu M concentration, percentile 5 was shortened (38 +/- 6 vs. 52 +/- 10ms; p<0.005) and the complexity index increased (1.77 +/- 0.18 vs. 1.27 +/- 0.13; p<0.0001). The greatest complexity indices (1.84 +/- 0.17; p<0.05) were obtained during stretch in this series. S-nitrosoglutathione 10 mu M attenuates the effects of mechanoelectric feedback, while at a concentration of 50 mu M the drug alters the baseline VF pattern and accentuates the increase in complexity of the arrhythmia induced by myocardial stretch. es_ES
dc.description.sponsorship Carlos III Health Institute/FEDER funds (Spanish Ministry of Economy and Competitiveness): Grants FIS PI12/00407, PI15/01408, PIE15/00013, and RETIC “RIC” RD12/0042/0048. Generalitat Valenciana: Grant PROMETEO FASE II 2014/037.
dc.language Inglés es_ES
dc.publisher Springer-Verlag es_ES
dc.relation.ispartof Cardiovascular Toxicology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Nitric oxide es_ES
dc.subject S-nitrosoglutathione es_ES
dc.subject Myocardial stretch es_ES
dc.subject Mechanoelectric feedback es_ES
dc.subject Cardiac arrhythmias es_ES
dc.subject Ventricular fibrillation es_ES
dc.subject Cardiac mapping es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Effects of S-Nitrosoglutathione on Electrophysiological Manifestations of Mechanoelectric Feedback es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s12012-018-9463-1 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2014%2F037/ES/ESTUDIO MEDIANTE TÉCNICAS CARTOGRÁFICAS AVANZADAS DE LOS MECANISMOS BÁSICOS IMPLICADOS EN LAS ARRITMIAS MALIGNAS Y EN SU CONTROL/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CB16%2F11%2F00486/ES/ENFERMEDADES CARDIOVASCULARES/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//PI12%2F00407/ES/Utilidad de la estabilización de la homeostasis del calcio intracelular en el control de los procesos fibrilatorios/
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//PI15%2F01408/ES/Efectos de la inhibición de la desacetilación de las histonas en el remodelado post-infarto del sustrato arritmogénico/
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//PIE15%2F00013/ES/A multidisciplinary project to advance in basic mechanisms, diagnosis, prediction, and prevention of cardiac damage in reperfused acute myocardial infarction/
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//RD12%2F0042%2F0048/ES/Enfermedades cardiovasculares/
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Such-Miquel, L.; Canto Serrano, ID.; Zarzoso Muñoz, M.; Brines-Ferrando, L.; Soler, C.; Parra-Giraldo, G.; Guill Ibáñez, A.... (2018). Effects of S-Nitrosoglutathione on Electrophysiological Manifestations of Mechanoelectric Feedback. Cardiovascular Toxicology. 18(6):520-529. https://doi.org/10.1007/s12012-018-9463-1 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1007/s12012-018-9463-1 es_ES
dc.description.upvformatpinicio 520 es_ES
dc.description.upvformatpfin 529 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 18 es_ES
dc.description.issue 6 es_ES
dc.identifier.pmid 29868937
dc.relation.pasarela S\380048 es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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