Barham, J.; Koyama, E.; Sugiyama, J.; Norikane, Y.; Egami, H.; Hamashima, Y. (2019). High Efficiency Microwave Flow Chemistry Towards Synthesis of Functional Materials and Pharmaceutical Cores. En AMPERE 2019. 17th International Conference on Microwave and High Frequency Heating. Editorial Universitat Politècnica de València. 409-417. https://doi.org/10.4995/AMPERE2019.2019.9860
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/130754
Título:
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High Efficiency Microwave Flow Chemistry Towards Synthesis of Functional Materials and Pharmaceutical Cores
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Autor:
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Barham, Joshua
Koyama, Emiko
Sugiyama, Jun-ichi
Norikane, Yasuo
Egami, Hiromichi
Hamashima, Yoshitaka
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Fecha difusión:
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Resumen:
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[EN] Microwave (MW) heating benefits organic synthesis by affording higher product yields in shorter time periods than conventional heating, yet it suffers from poor scalability and is limited to polar solvents in typical ...[+]
[EN] Microwave (MW) heating benefits organic synthesis by affording higher product yields in shorter time periods than conventional heating, yet it suffers from poor scalability and is limited to polar solvents in typical batch mode reactors. Herein, we report a microwave flow reactor using a solid-state semiconductor MW generator. The tunable, single-mode MW heating allows high efficiency, scalable organic synthesis, rapid reaction optimization and is applicable to non-polar solvents (o-Xylene and CPME can be rapidly heated to ca. 260 oC). Auto-frequency tuning compensates for changes in the microwave absorption properties (permittivity, epsilon) with increasing temperature, affording excellent temperature and process control. This technology unlocked unprecedented g/h productivity of C60/fullerene-indene monoadduct (IC60MA) and facilitated a novel, transition metal-free amide-styrene coupling reaction for synthesis of amide-containing pharmaceutical cores in up to 65 g/h (Figure 1). An ortho-Claisen rearrangement reaction was rapidly optimised.
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Palabras clave:
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Energy Production by Microwaves
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Microwave CVD
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EM Modelling
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Microwave Material interaction
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Dielectric Properties
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Dielectric Properties Measurement
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Solid State Microwave
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Microwave Processing
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Microwave Chemistry
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Microwave applicators design
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Derechos de uso:
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Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
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ISBN:
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9788490487198
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Fuente:
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AMPERE 2019. 17th International Conference on Microwave and High Frequency Heating.
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DOI:
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10.4995/AMPERE2019.2019.9860
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Editorial:
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Editorial Universitat Politècnica de València
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Versión del editor:
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http://ocs.editorial.upv.es/index.php/AMPERE2019/AMPERE2019/paper/view/9860
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Título del congreso:
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Ampere 2019
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Lugar del congreso:
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Valencia, Spain
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Fecha congreso:
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Septiembre 09-12,2019
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Código del Proyecto:
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info:eu-repo/grantAgreement/JSPS//JP18F19030/
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Agradecimientos:
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The authors gratefully acknowledge the technical support from the National Institute of
Advanced Industrial Science and Technology and the University of Shizuoka, as well as
financial support from NEDO, Shizuoka Prefectural ...[+]
The authors gratefully acknowledge the technical support from the National Institute of
Advanced Industrial Science and Technology and the University of Shizuoka, as well as
financial support from NEDO, Shizuoka Prefectural Government. Joshua P. Barham is
grateful for financial support from JSPS (KAKENHI Grant Number JP18F19030). The
authors are grateful for Shizuoka University (Prof. Noboyuki Mase’s group) and Gifu
Pharmaceutical University (Prof. Hironao Sajiki’s group) for their research in this area.
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Tipo:
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Capítulo de libro
Comunicación en congreso
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