Lluna Galán, C.; Blay, G.; Fernández, I.; Muñoz Roca, MDC.; Pedro, JR.; Vila, C. (2018). Organocatalytic Enantioselective Strecker Reaction with Seven-Membered Cyclic Imines. Advanced Synthesis & Catalysis. 360(19):3662-3666. https://doi.org/10.1002/adsc.201800754
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/132857
Title:
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Organocatalytic Enantioselective Strecker Reaction with Seven-Membered Cyclic Imines
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Author:
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Lluna Galán, C.
Blay, G.
Fernández, I.
Muñoz Roca, María Del Carmen
Pedro, J. R.
Vila, C.
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UPV Unit:
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Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada
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Issued date:
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Abstract:
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[EN] A highly enantioselective Strecker reaction with dibenzo[b,f][1,4]oxazepines has been described using a dihydroquinine-derived thiourea as organocatalyst. The reaction affords chiral 10,11-dihydrodibenzo[b,f][1,4] ...[+]
[EN] A highly enantioselective Strecker reaction with dibenzo[b,f][1,4]oxazepines has been described using a dihydroquinine-derived thiourea as organocatalyst. The reaction affords chiral 10,11-dihydrodibenzo[b,f][1,4] oxazepine 11-carbonitrile derivatives in excellent yields (up to 99%) and excellent enantioselectivities (up to 98%) under mild reaction conditions.
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Subjects:
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Asymmetric catalysis
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Organocatalysis
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Strecker reaction
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Dibenzo[b,f][1,4]oxazepines
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Alpha-amino nitriles
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Copyrigths:
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Reserva de todos los derechos
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Source:
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Advanced Synthesis & Catalysis. (issn:
1615-4150
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DOI:
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10.1002/adsc.201800754
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Publisher:
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John Wiley & Sons
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Publisher version:
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https://doi.org/10.1002/adsc.201800754
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Project ID:
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info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-84900-P/ES/REACCIONES DE ADICION ENANTIOSELECTIVAS MEDIANTE SISTEMAS MULTICATALITICOS. HERRAMIENTAS PARA LA SINTESIS EFICIENTE DE MOLECULAS CON ACTIVIDAD FARMACOLOGICA/
info:eu-repo/grantAgreement/MINECO//RYC-2016-20187/
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Thanks:
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Financial support from the Agencia Estatal de Investigacion (Spanish Government) and Fondo Europeo de Desarrollo Regional (FEDER, European Union) (CTQ2017-84900-P) is acknowledged. C. V. thanks the Spanish Government for ...[+]
Financial support from the Agencia Estatal de Investigacion (Spanish Government) and Fondo Europeo de Desarrollo Regional (FEDER, European Union) (CTQ2017-84900-P) is acknowledged. C. V. thanks the Spanish Government for a Ramon y Cajal contract (RyC-2016-20187). Access to NMR, MS and X-ray facilities from the Servei central de suport a la investigacio experimental (SCSIE)-UV is also acknowledged.
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Type:
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Artículo
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