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Investigation of Different Iontophoretic Currents Profiles for Short-Term Applications in Cosmetics

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Investigation of Different Iontophoretic Currents Profiles for Short-Term Applications in Cosmetics

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dc.contributor.author Cázares-Delgadillo, J. es_ES
dc.contributor.author Planard-Luong, L. es_ES
dc.contributor.author Gregoire, S. es_ES
dc.contributor.author Serna-Jiménez, C. E. es_ES
dc.contributor.author Singhal, Mayank es_ES
dc.contributor.author Kalia, Yogeshvar N. es_ES
dc.contributor.author Merino Sanjuán, Virginia es_ES
dc.contributor.author Merino sanjuán, Matilde es_ES
dc.contributor.author Nacher Alonso, Amparo es_ES
dc.contributor.author Martinez-Gomez, M. A. es_ES
dc.contributor.author Burnier-Yalaoui, V. es_ES
dc.contributor.author Barbarat, P. es_ES
dc.date.accessioned 2020-01-09T21:00:49Z
dc.date.available 2020-01-09T21:00:49Z
dc.date.issued 2018 es_ES
dc.identifier.uri http://hdl.handle.net/10251/134139
dc.description.abstract [EN] This study aimed at investigating the effect of electrical current profile upon the iontophoretic transport of (i) ascorbic acid (AA) and (ii) ellagic acid (EA), into porcine skin in vitro, and the impact of the physicochemical properties of both actives on their mechanism of transport when formulated in cosmetic compositions. The experiments were performed using a proprietary iontophoretic device containing a roller to apply the formulation. Three current profiles were tested: (i) galvanic direct current (DC), (ii) square unipolar pulse current (SPC), and (iii) galvanic direct current (DC) + pulse current (PC). The skin samples were collected at different sampling points, extracted and analyzed by HPLC. Results suggested that the DC + PC mode for only 5 min was able to significantly increase the delivery of AA from o/w cosmetic compositions. The use of this current profile might improve the skin penetration of AA due to electromigration and passive diffusion, the latter being facilitated by the physical enhancement method. The SPC mode significantly improved the passage of EA in its neutral form from cosmetic o/w formulations by electroosmosis. Tailoring specific electrical current modes considering the ionization state of active ingredients would allow the design of short and personalized cosmetic treatments that significantly improve the penetration efficiency of the active ingredients and possibly reduce the doses applied. es_ES
dc.description.sponsorship This research was entirely funded by L'Oreal, France. es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Pharmaceutics es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Iontophoresis es_ES
dc.subject Topical penetration es_ES
dc.subject Ascorbic acid es_ES
dc.subject Ellagic acid es_ES
dc.subject Pulsed current es_ES
dc.subject Galvanic current es_ES
dc.subject Square unipolar pulse current es_ES
dc.title Investigation of Different Iontophoretic Currents Profiles for Short-Term Applications in Cosmetics es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/pharmaceutics10040266 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.description.bibliographicCitation Cázares-Delgadillo, J.; Planard-Luong, L.; Gregoire, S.; Serna-Jiménez, CE.; Singhal, M.; Kalia, YN.; Merino Sanjuán, V.... (2018). Investigation of Different Iontophoretic Currents Profiles for Short-Term Applications in Cosmetics. Pharmaceutics. 10(4). https://doi.org/10.3390/pharmaceutics10040266 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/pharmaceutics10040266 es_ES
dc.description.upvformatpinicio 266 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 10 es_ES
dc.description.issue 4 es_ES
dc.identifier.eissn 1999-4923 es_ES
dc.relation.pasarela S\383213 es_ES
dc.contributor.funder L'Oréal
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