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dc.contributor.author | Picó-Marco, Enric | es_ES |
dc.contributor.author | Boada-Acosta, Yadira Fernanda | es_ES |
dc.contributor.author | Picó, Jesús | es_ES |
dc.contributor.author | Vignoni, Alejandro | es_ES |
dc.date.accessioned | 2020-02-07T21:02:24Z | |
dc.date.available | 2020-02-07T21:02:24Z | |
dc.date.issued | 2016 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/136476 | |
dc.description.abstract | [EN] We consider a realistic model of the synthetic gene circuit combining cell-to-cell communication system via quorum sensing, and a synthetic repressible promoter implementing intracellular negative feedback control. The circuit has been shown to increase robustness with respect to both extrinsic and intrinsic noise elsewhere. As a first step towards an analytic analysis, in this paper we use contraction theory to perform a stability analysis. From it, we infer the components of the circuit most affecting the rate of contractivity, using biologically sensible values of the circuit parameters. | es_ES |
dc.description.sponsorship | This research was partially funded by grant FEDER-CICYT DPI2014-55276-C5-1-R. Yadira Boada thanks grant FPI/2013-3242 of the Universitat Politècnica de València. | |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | IFAC-PapersOnLine | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Synthetic biology | es_ES |
dc.subject | Cell-to-cell communication | es_ES |
dc.subject | Differential stability | es_ES |
dc.subject | Contractivity | es_ES |
dc.subject.classification | INGENIERIA DE SISTEMAS Y AUTOMATICA | es_ES |
dc.title | Contractivity of a genetic circuit with internal feedback and cell-to-cell communication | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.ifacol.2016.12.128 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//DPI2014-55276-C5-1-R/ES/BIOLOGIA SINTETICA PARA LA MEJORA EN BIOPRODUCCION: DISEÑO, OPTIMIZACION, MONITORIZACION Y CONTROL/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/UPV//FPI%2F2013-3242/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Ingeniería de Sistemas y Automática - Departament d'Enginyeria de Sistemes i Automàtica | es_ES |
dc.description.bibliographicCitation | Picó-Marco, E.; Boada-Acosta, YF.; Picó, J.; Vignoni, A. (2016). Contractivity of a genetic circuit with internal feedback and cell-to-cell communication. IFAC-PapersOnLine. 49(26):213-218. https://doi.org/10.1016/j.ifacol.2016.12.128 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.ifacol.2016.12.128 | es_ES |
dc.description.upvformatpinicio | 213 | es_ES |
dc.description.upvformatpfin | 218 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 49 | es_ES |
dc.description.issue | 26 | es_ES |
dc.identifier.eissn | 2405-8963 | es_ES |
dc.relation.pasarela | S\325476 | es_ES |
dc.contributor.funder | Universitat Politècnica de València | |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |