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Contractivity of a genetic circuit with internal feedback and cell-to-cell communication

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Contractivity of a genetic circuit with internal feedback and cell-to-cell communication

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dc.contributor.author Picó-Marco, Enric es_ES
dc.contributor.author Boada-Acosta, Yadira Fernanda es_ES
dc.contributor.author Picó, Jesús es_ES
dc.contributor.author Vignoni, Alejandro es_ES
dc.date.accessioned 2020-02-07T21:02:24Z
dc.date.available 2020-02-07T21:02:24Z
dc.date.issued 2016 es_ES
dc.identifier.uri http://hdl.handle.net/10251/136476
dc.description.abstract [EN] We consider a realistic model of the synthetic gene circuit combining cell-to-cell communication system via quorum sensing, and a synthetic repressible promoter implementing intracellular negative feedback control. The circuit has been shown to increase robustness with respect to both extrinsic and intrinsic noise elsewhere. As a first step towards an analytic analysis, in this paper we use contraction theory to perform a stability analysis. From it, we infer the components of the circuit most affecting the rate of contractivity, using biologically sensible values of the circuit parameters. es_ES
dc.description.sponsorship This research was partially funded by grant FEDER-CICYT DPI2014-55276-C5-1-R. Yadira Boada thanks grant FPI/2013-3242 of the Universitat Politècnica de València.
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation FEDER-CICYT/DPI2014-55276-C5-1-R es_ES
dc.relation UPV/FPI/2013-3242 es_ES
dc.relation.ispartof IFAC-PapersOnLine es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Synthetic biology es_ES
dc.subject Cell-to-cell communication es_ES
dc.subject Differential stability es_ES
dc.subject Contractivity es_ES
dc.subject.classification INGENIERIA DE SISTEMAS Y AUTOMATICA es_ES
dc.title Contractivity of a genetic circuit with internal feedback and cell-to-cell communication es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.ifacol.2016.12.128 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería de Sistemas y Automática - Departament d'Enginyeria de Sistemes i Automàtica es_ES
dc.description.bibliographicCitation Picó-Marco, E.; Boada-Acosta, YF.; Picó, J.; Vignoni, A. (2016). Contractivity of a genetic circuit with internal feedback and cell-to-cell communication. IFAC-PapersOnLine. 49(26):213-218. https://doi.org/10.1016/j.ifacol.2016.12.128 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.ifacol.2016.12.128 es_ES
dc.description.upvformatpinicio 213 es_ES
dc.description.upvformatpfin 218 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 49 es_ES
dc.description.issue 26 es_ES
dc.identifier.eissn 2405-8963 es_ES
dc.relation.pasarela S\325476 es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Comisión Interministerial de Ciencia y Tecnología es_ES
dc.contributor.funder Universitat Politècnica de València


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