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Tx, TqNet and Ttriang Values

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Tx, TqNet and Ttriang Values

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Llopis Lorente, J.; Gomis-Tena Dolz, J.; Cano García, J.; Romero Pérez, L.; Saiz Rodríguez, FJ.; Trénor Gomis, BA. (2020). Tx, TqNet and Ttriang Values. https://doi.org/10.4995/Dataset/10251/136919

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/136919

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Title: Tx, TqNet and Ttriang Values
Secondary Title: In-Silico Classifiers for Assessment of Drug Proarrhytmicity
UPV Unit: Universitat Politècnica de València. Centro de Investigación e Innovación en Bioingeniería
Issued date:
This repository contains the Matlab functions used in [1] and six Excel files named “Tx matrix KrKsCaL.xlsx”, “Tx matix KrNaLCaL.xlsx”, “TqNet matrix KrKsCaL.xlsx”, “TqNet matrix KrNaLCaL.xlsx”, "Ttirang matrix KrKsCaL.xlsx" ...[+]
Subjects: drug-induced Torsade de Pointes , cardiac safety , Tx , TqNet , Ttriang
Copyrigths: Reconocimiento - No comercial (by-nc)
DOI: 10.4995/Dataset/10251/136919
Description: Every sheet in described files contains a table of numbers (doubles), resulting from the transformation of a three-dimensional matrix. To do so, the first three columns of each table contain the Coordinates x, y and z or z' of the original matrix respectively (no units). They range from -3 to 1.5. Coordinates were calculated as the logarithm of the ratio of a drug concentration (C) over the concentration that is required to inhibit a 50% of a given ion channel current (Half inhibitory concentration or IC50). They represent the block effect of such drug on four main currents which control the Action Potential shape and duration, namely, the rapid component of the potassium delayed rectifier current (IKr), the slow component of the potassium delayed rectifier current (IKs), the late sodium current (INaL) and the calcium type L current (ICaL). The following formulae can be used to deduce mentioned Coordinates: x = log_10(C/(IC_50 (I_Kr))) ; y = log_10(C/(IC_50 (I_CaL ) )); z = log_10(C/(IC_50 (I_CaL)); and z' = log_10(C/(IC_50 (I_NaL)). These are indeed part of the Hill equation (Hill coefficient set to 1), where G is the channel’s resulting conductance and G0 is the channel’s control conductance: G_[x || y || z || z'] = G_0·1/(1+C/(IC_(50, [x || y || z || z'] ) )) = G_0·1/(1+10^([x || y || z || z']) ). Conductances of the four main currents are thus translated into cardiac cellular or tissue models to study the effect of a wide range of drug concentrations. The following parameters were obtained and summarized in currently described files. Detailed methods of the performed simulations, as well as biomarker calculations, can be consulted in [1].
The authors would like to strongly thank Dr. Manuel Pastor from Research Programme on Biomedical Informatics (GRIB), at Universitat Pompeu Fabra (Barcelona, Spain) for its review of the manuscript and expert opinions and ...[+]
Type: Dataset

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