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Molecular subtypes in early colorectal cancer associated with clinical features and patient prognosis

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Molecular subtypes in early colorectal cancer associated with clinical features and patient prognosis

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Nombre: Gil-Raga;Jantus-L ...
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dc.contributor.author Gil-Raga, Mireia es_ES
dc.contributor.author Jantus-Lewintre, Eloisa es_ES
dc.contributor.author Gallach-Garcia, Sandra es_ES
dc.contributor.author Giner-Bosch, Vicent es_ES
dc.contributor.author Frangi-Caregnato, Alejandro Federico es_ES
dc.contributor.author Safont-Aguilera, María José es_ES
dc.contributor.author Garde-Noguera, Javier es_ES
dc.contributor.author Zorraquino-Pina, Estefanía es_ES
dc.contributor.author García-Martínez, Marisa es_ES
dc.contributor.author Camps-Herrero, Carlos es_ES
dc.date.accessioned 2020-02-16T21:01:48Z
dc.date.available 2020-02-16T21:01:48Z
dc.date.issued 2018 es_ES
dc.identifier.issn 1699-048X es_ES
dc.identifier.uri http://hdl.handle.net/10251/137018
dc.description.abstract [EN] PurposeAfter surgical resection, an ample prognosis variability among stages is observed. Multiple prognostic factors are individually studied and some CRC classifiers have been proposed. Not one have been implemented into clinical practice.Methods/patientsWe classified 105 patients with resected CRC (stage I-III) into five molecular subtypes using BRAF(V600E) and RAS (KRAS; NRAS) status, and the expression of DNA mismatch repair (MMR) proteins (MLH1 and MSH2). Clinicopathological features and DFS) of distincts groups were evaluated.Results and conclusionsRAS and BRAF(V600E) mutations were detected in 43.8 and 11.4% of patients, respectively. 19% of tumours had lack of expression of any MMR proteins reflecting a system deficiency (dMMR). Patients with any RAS mutation had lower DFS that patients with RAS wild type (wt) (40.23 vs 45.26months; p value=0.035). Of a total of five molecular subtypes, three were MMR proficient (pMMR): RAS mutated (39%), BRAF(V600E) mutated (6.7%) and RAS/BRAF(V600E) wt (35.2%); and two were dMMR: BRAF(V600E) mutated (4.8%) and BRAF(V600E) wt (14.3%). Left side tumours were more frequently observed in pMMR/RAS and BRAF(V600E) wt subtype, and right side tumours in dMMR subtypes. Among the three pMMR subtypes, a benefit survival was observed for patients without any mutation in BRAF(v600E) or RAS oncogenes (median of DFS=45.5 vs 40.98months in RAS mutated group; p=0.084 and vs 34.13 in BRAF(v600E) mutated group; p=0.031). Molecular classification using these biomarkers can be useful to identify groups with differences in prognosis. es_ES
dc.language Inglés es_ES
dc.publisher Springer-Verlag es_ES
dc.relation.ispartof Clinical & Translational Oncology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Colorectal cancer es_ES
dc.subject Prognostic factor es_ES
dc.subject Molecular subtypes es_ES
dc.subject.classification BIOLOGIA CELULAR es_ES
dc.subject.classification ESTADISTICA E INVESTIGACION OPERATIVA es_ES
dc.title Molecular subtypes in early colorectal cancer associated with clinical features and patient prognosis es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s12094-018-1874-8 es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Estadística e Investigación Operativa Aplicadas y Calidad - Departament d'Estadística i Investigació Operativa Aplicades i Qualitat es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.description.bibliographicCitation Gil-Raga, M.; Jantus-Lewintre, E.; Gallach-Garcia, S.; Giner-Bosch, V.; Frangi-Caregnato, AF.; Safont-Aguilera, MJ.; Garde-Noguera, J.... (2018). Molecular subtypes in early colorectal cancer associated with clinical features and patient prognosis. Clinical & Translational Oncology. 20(11):1422-1429. https://doi.org/10.1007/s12094-018-1874-8 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1007/s12094-018-1874-8 es_ES
dc.description.upvformatpinicio 1422 es_ES
dc.description.upvformatpfin 1429 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 20 es_ES
dc.description.issue 11 es_ES
dc.relation.pasarela S\373614 es_ES
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