Sancho-Fornes, G.; Avella-Oliver, M.; Carrascosa Rubio, J.; Fernández-Sánchez, ME.; Brun, EM.; Maquieira Catala, Á. (2019). Disk-based one-dimensional photonic crystal slabs for label-free immunosensing. Biosensors and Bioelectronics. 126:315-323. https://doi.org/10.1016/j.bios.2018.11.005
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/137598
Title:
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Disk-based one-dimensional photonic crystal slabs for label-free immunosensing
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Author:
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Sancho-Fornes, Gabriel
Avella-Oliver, Miquel
Carrascosa Rubio, Javier
Fernández-Sánchez, María Estrella
Brun, Eva M.
Maquieira Catala, Ángel
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UPV Unit:
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Universitat Politècnica de València. Departamento de Química - Departament de Química
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Issued date:
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Abstract:
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[EN] One-dimensional photonic crystal slabs are periodic optical nanostructures that produce guided-mode resonance. They couple part of the incident light into the waveguide generating bandgaps in the transmittance spectrum, ...[+]
[EN] One-dimensional photonic crystal slabs are periodic optical nanostructures that produce guided-mode resonance. They couple part of the incident light into the waveguide generating bandgaps in the transmittance spectrum, whose position is sensitive to refractive index variations on their surface. In this study, we present one-dimensional photonic crystal slab biosensors based on the internal nanogrooved structure of Blu-ray disks for label-free immunosensing. We demonstrated that this polycarbonate structure coated with a critical thickness of TiO2 generates guided-mode resonance. Its optical behavior was established comparing it with other compact disk structures. The results were theoretically calculated and experimentally demonstrated, all them being in agreement. The bioanalytical performance of these photonic crystals was experimentally demonstrated in a model assay to quantify IgGs as well as in two immunoassays to determine the biomarkers C-reactive protein and lactate dehydrogenase (detection limits of 0.1, 87, and 13 nM, respectively). The results are promising towards the development of new low-cost, portable, and label-free optical biosensors that join these photonic crystals with dedicated bioanalytical scanners based on compact disk drives.
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Subjects:
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Photonic crystal
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Guided-mode resonance
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Diffraction
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Blu-ray
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Immunosensing
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Label-free
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Copyrigths:
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Reserva de todos los derechos
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Source:
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Biosensors and Bioelectronics. (issn:
0956-5663
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DOI:
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10.1016/j.bios.2018.11.005
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Publisher:
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Elsevier
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Publisher version:
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https://doi.org/10.1016/j.bios.2018.11.005
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Project ID:
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info:eu-repo/grantAgreement/MINECO//CTQ2013-45875-R/ES/BIOSENSADO EN SOPORTES INTERACTIVOS CON PROPIEDADES INTERFEROMETRICAS PARA APLICACIONES CLINICAS. DEMOSTRACION EN FARMACOGENETICA Y ALERGIAS MEDICAMENTOSAS/
info:eu-repo/grantAgreement/MINECO//CTQ2016-75749-R/ES/BIOSENSORES HOLOGRAFICOS. PRUEBA DE CONCEPTO Y DEMOSTRACION EN APLICACIONES CLINICAS/
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Thanks:
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This research was supported by FEDER grants and the Spanish Ministry of Economy and Competitiveness projects (CTQ2013-45875-R and CTQ2016-75749-R).
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Type:
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Artículo
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