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Feasibility Study of a Small Animal PET Insert Based on a Single LYSO Monolithic Tube

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Feasibility Study of a Small Animal PET Insert Based on a Single LYSO Monolithic Tube

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dc.contributor.author González Martínez, Antonio Javier es_ES
dc.contributor.author Berr, Stuart S. es_ES
dc.contributor.author Cañizares-Ledo, Gabriel es_ES
dc.contributor.author Gonzalez-Montoro, Andrea es_ES
dc.contributor.author Orero Palomares, Abel es_ES
dc.contributor.author Correcher Salvador, Carlos es_ES
dc.contributor.author Rezaei, Ahmadreza es_ES
dc.contributor.author Nuyts, Johan es_ES
dc.contributor.author Sanchez, Filomeno es_ES
dc.contributor.author Majewski, Stan es_ES
dc.contributor.author Benlloch Baviera, Jose María es_ES
dc.date.accessioned 2020-03-24T06:14:11Z
dc.date.available 2020-03-24T06:14:11Z
dc.date.issued 2018-11-28 es_ES
dc.identifier.uri http://hdl.handle.net/10251/139238
dc.description.abstract [EN] There are drawbacks with using a Positron Emission Tomography (PET) scanner design employing the traditional arrangement of multiple detectors in an array format. Typically PET systems are constructed with many regular gaps between the detector modules in a ring or box configuration, with additional axial gaps between the rings. Although this has been significantly reduced with the use of the compact high granularity SiPM photodetector technology, such a scanner design leads to a decrease in the number of annihilation photons that are detected causing lower scanner sensitivity. Moreover, the ability to precisely determine the line of response (LOR) along which the positron annihilated is diminished closer to the detector edges because the spatial resolution there is degraded due to edge effects. This happens for both monolithic based designs, caused by the truncation of the scintillation light distribution, but also for detector blocks that use crystal arrays with a number of elements that are larger than the number of photosensors and, therefore, make use of the light sharing principle. In this report we present a design for a small-animal PET scanner based on a single monolithic annulus-like scintillator that can be used as a PET insert in high-field Magnetic Resonance systems. We provide real data showing the performance improvement when edge-less modules are used. We also describe the specific proposed design for a rodent scanner that employs facetted outside faces in a single LYSO tube. In a further step, in order to support and prove the proposed edgeless geometry, simulations of that scanner have been performed and lately reconstructed showing the advantages of the design. es_ES
dc.description.sponsorship This project was funded in part by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No 695536). It has also been supported by the Spanish Ministerio de Economia, Industria y Competitividad under Grant TEC2016-79884-C2-1-R and through PROSPET (DTS15/00152) funded by the Ministerio de Economia y Competitividad. AR is a postdoctoral fellow of the FWO (project 12T7118N). The University of Virginia School of Medicine has provided seed funding for this project. es_ES
dc.language Inglés es_ES
dc.publisher Frontiers Media es_ES
dc.relation.ispartof Frontiers in Medicine es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Positron emission tomography es_ES
dc.subject Hybrid PET-MR es_ES
dc.subject Monolithic crystal es_ES
dc.subject SiPM es_ES
dc.subject Preclinical imaging es_ES
dc.title Feasibility Study of a Small Animal PET Insert Based on a Single LYSO Monolithic Tube es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3389/fmed.2018.00328 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//TEC2016-79884-C2-1-R/ES/DESARROLLO DEL HARDWARE PARA SISTEMA DE DIAGNOSTICO POR IMAGEN MOLECULAR PARA CORAZON EN CONDICIONES DE ESTRES/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//DTS15%2F00152/ES/Desarrollo de un detector PET para guiar la biopsia, el tratamiento y el seguimiento del cáncer de próstata (PROSPECT)/
dc.relation.projectID info:eu-repo/grantAgreement/FWO//12T7118N/
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular es_ES
dc.description.bibliographicCitation González Martínez, AJ.; Berr, SS.; Cañizares-Ledo, G.; Gonzalez-Montoro, A.; Orero Palomares, A.; Correcher Salvador, C.; Rezaei, A.... (2018). Feasibility Study of a Small Animal PET Insert Based on a Single LYSO Monolithic Tube. Frontiers in Medicine. 5:1-8. https://doi.org/10.3389/fmed.2018.00328 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3389/fmed.2018.00328 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 8 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 5 es_ES
dc.identifier.eissn 2296-858X es_ES
dc.relation.pasarela S\406064 es_ES
dc.contributor.funder European Commission es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Research Foundation Flanders
dc.contributor.funder University of Virginia
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