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Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection

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Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection

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dc.contributor.author Polo, Lorena es_ES
dc.contributor.author Gómez-Cerezo, Natividad es_ES
dc.contributor.author Aznar, Elena es_ES
dc.contributor.author Vivancos, José-Luis es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.contributor.author Arcos, Daniel es_ES
dc.contributor.author Vallet, María es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.date.accessioned 2020-03-30T07:22:20Z
dc.date.available 2020-03-30T07:22:20Z
dc.date.issued 2017 es_ES
dc.identifier.issn 1742-7061 es_ES
dc.identifier.uri http://hdl.handle.net/10251/139775
dc.description.abstract [EN] Silica mesoporous nanomaterials have been proved to have meaningful application in biotechnology and biomedicine. Particularly, mesoporous bioactive glasses are recently gaining importance thanks to their bone regenerative properties. Moreover, the mesoporous nature of these materials makes them suitable for drug delivery applications, opening new lines in the field of bone therapies. In this work, we have developed innovative nanodevices based on the implementation of adenosine triphosphate (ATP) and e-poly-l-lysine molecular gates using a mesoporous bioglass as an inorganic support. The systems have been previously proved to work properly with a fluorescence probe and subsequently with an antibiotic(levofloxacin) and an antitumoral drug(doxorubicin). The bioactivity of the prepared materials has also been tested, giving promising results. Finally, in vitro cell culture studies have been carried out; demonstrating that this gated devices can provide useful approaches for bone cancer and bone infection treatments. es_ES
dc.description.sponsorship Spanish Government for projects MAT2015-64139-C04-01-R, MAT-2013-43299-R, MAT2015-64831-R (MINECO/FEDER) and for project CS02010-11384-E (Agening-MICINN). Also, Generalitat Valenciana (project PROMETEOII/2014/047) and CIBER-BBN (project SPRING) are acknowledged for their support. MVR acknowledges funding from the European Research Council (Advanced Grant VERDI; ERC-2015-AdG Proposal No. 694160). LP thanks Universitat Politecnica de Valencia for her FPI grant. NGC is greatly indebted to Ministerio de Ciencia e Innovation for her predoctoral fellowship. The authors also wish to thank the staff of the ICTS Centro Nacional de Microscopia Electronica of the Universidad Complutense de Madrid (Spain) for the assistance in the scanning electron microscopy. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Acta Biomaterialia es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Biomaterials es_ES
dc.subject Controlled release es_ES
dc.subject Gated mesoporous bioactive glasses es_ES
dc.subject.classification CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA es_ES
dc.subject.classification PROYECTOS DE INGENIERIA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.title Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.actbio.2016.12.025 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2013-43299-R/ES/ESTRUCTURAS MACROPOROSAS ASOCIADAS A FACTORES DE CRECIMIENTO PARA LA RECONSTRUCCION DE DEFECTOS OSEOS Y DEFECTOS EN HUESO OSTEOPOROTICO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/694160/EU/polyValent mEsopoRous nanosystem for bone DIseases/
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2015-64831-R/ES/NANOSISTEMA POLIVALENTE CAPAZ DE APORTAR SOLUCIONES PARA HUESO INFECTADO, CON CANCER Y OSTEOPOROTICO./ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2014%2F047/ES/Nuevas aproximaciones para el diseño de materiales de liberación controlada y la detección de compuestos peligrosos/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2015-64139-C4-1-R/ES/NANOMATERIALES INTELIGENTES, SONDAS Y DISPOSITIVOS PARA EL DESARROLLO INTEGRADO DE NUEVAS HERRAMIENTAS APLICADAS AL CAMPO BIOMEDICO/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Mecánica y de Materiales - Departament d'Enginyeria Mecànica i de Materials es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Proyectos de Ingeniería - Departament de Projectes d'Enginyeria es_ES
dc.description.bibliographicCitation Polo, L.; Gómez-Cerezo, N.; Aznar, E.; Vivancos, J.; Sancenón Galarza, F.; Arcos, D.; Vallet, M.... (2017). Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection. Acta Biomaterialia. 50:114-126. https://doi.org/10.1016/j.actbio.2016.12.025 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.actbio.2016.12.025 es_ES
dc.description.upvformatpinicio 114 es_ES
dc.description.upvformatpfin 126 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 50 es_ES
dc.relation.pasarela S\324771 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder European Commission es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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