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Viroids: survivors from the RNA world?

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Viroids: survivors from the RNA world?

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dc.contributor.author FLORES PEDAUYE, RICARDO es_ES
dc.contributor.author Gago Zachert, Selma Persida es_ES
dc.contributor.author SERRA ALFONSO, PEDRO es_ES
dc.contributor.author Sanjuan Verdeguer, Rafael es_ES
dc.contributor.author ELENA FITO, SANTIAGO FCO es_ES
dc.date.accessioned 2020-04-01T07:15:24Z
dc.date.available 2020-04-01T07:15:24Z
dc.date.issued 2014 es_ES
dc.identifier.issn 0066-4227 es_ES
dc.identifier.uri http://hdl.handle.net/10251/139923
dc.description.abstract [EN] Because RNA can be a carrier of genetic information and a biocatalyst, there is a consensus that it emerged before DNA and proteins, which eventually assumed these roles and relegated RNA to intermediate functions. If such a scenario¿the so-calledRNAworld¿existed,wemight hope to find its relics in our presentworld. The properties of viroids that make them candidates for being survivors of the RNA world include those expected for primitive RNA replicons: (a) small size imposed by error-prone replication, (b) high G + C content to increase replication fidelity, (c) circular structure for assuring complete replication without genomic tags, (d ) structural periodicity for modular assembly into enlarged genomes, (e) lack of protein-coding ability consistent with a ribosome-free habitat, and ( f ) replication mediated in some by ribozymes, the fingerprint of the RNA world. With the advent of DNA and proteins, those protoviroids lost some abilities and became the plant parasites we now know. es_ES
dc.description.sponsorship R.F. has received funding by grant BFU2011-28443 from Ministerio de Economia y Competititvidad (MINECO, Spain), R.S. by grants BFU2011-25271 (MINECO) and ERC-2011-StG-281191-VIRMUT (European Research Council), and S.F.E. by grant BFU2012-30805 (MINECO). P.S. has been supported by postdoctoral contracts from Generalitat Valenciana (APOSTD/2010, program VALi+d) and MINECO (program Juan de la Cierva). es_ES
dc.language Inglés es_ES
dc.publisher Annual Reviews es_ES
dc.relation MINECO/BFU2011-28443 es_ES
dc.relation MINECO/BFU2012-30805 es_ES
dc.relation MINECO/BFU2011-25271 es_ES
dc.relation ERC/ERC-2011-StG-281191-VIRMUT es_ES
dc.relation GV/APOSTD/2010 es_ES
dc.relation.ispartof Annual Review of Microbiology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Viroid-like satellite RNAs es_ES
dc.subject Hepatitis delta virus es_ES
dc.subject Catalytic RNAs es_ES
dc.subject Hammerhead ribozymes es_ES
dc.subject Small noncoding RNAs es_ES
dc.title Viroids: survivors from the RNA world? es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1146/annurev-micro-091313-103416 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/281191/EU es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation Flores Pedauye, R.; Gago Zachert, SP.; Serra Alfonso, P.; Sanjuan Verdeguer, R.; Elena Fito, SF. (2014). Viroids: survivors from the RNA world?. Annual Review of Microbiology. 68:395-414. https://doi.org/10.1146/annurev-micro-091313-103416 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1146/annurev-micro-091313-103416 es_ES
dc.description.upvformatpinicio 395 es_ES
dc.description.upvformatpfin 414 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 68 es_ES
dc.relation.pasarela S\266233 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder European Research Council es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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