Jimenez-Falcao, S.; De Luis-Fernández, B.; García-Fernández, A.; Llopis-Lorente, A.; Diez-Sánchez, P.; Sánchez, A.; Sancenón Galarza, F.... (2019). Glucose-Responsive Enzyme-Controlled Mesoporous Nanomachine with a Layer-by-Layer Supramolecular Architecture. ACS Applied Bio Materials. 2(8):3321-3328. https://doi.org/10.1021/acsabm.9b00338
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/140819
Title:
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Glucose-Responsive Enzyme-Controlled Mesoporous Nanomachine with a Layer-by-Layer Supramolecular Architecture
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Author:
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Jimenez-Falcao, S.
de Luis-Fernández, Beatriz
García-Fernández, Alba
Llopis-Lorente, Antoni
Diez-Sánchez, Paula
Sánchez, Alfredo
Sancenón Galarza, Félix
Martínez-Ruiz, Paloma
Martínez-Máñez, Ramón
Villalonga, Reynaldo
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UPV Unit:
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Universitat Politècnica de València. Departamento de Química - Departament de Química
Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia
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Issued date:
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Abstract:
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[EN] Here we describe the construction of an integrated and pH-sensitive nanomachine with layer-by-layer supramolecular design and enzymatic control for on-command delivery. The nanodevice comprises a first layer of ...[+]
[EN] Here we describe the construction of an integrated and pH-sensitive nanomachine with layer-by-layer supramolecular design and enzymatic control for on-command delivery. The nanodevice comprises a first layer of ß-cyclodextrin-coated gold nanoparticles as capping element of benzimidazole functionalized mesoporous silica nanoparticles, and a second control layer based on an adatamantane-modified glucose oxidase derivative. The nanomachine was selectively fuelled by glucose and successfully employed for the autonomous release of doxorubicin in HeLa cancer cells.
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Subjects:
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Cyclodextrin: Enzymes
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Mesoporous silica
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Delivery
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Gold nanoparticles
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Copyrigths:
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Reserva de todos los derechos
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Source:
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ACS Applied Bio Materials. (eissn:
2576-6422
)
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DOI:
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10.1021/acsabm.9b00338
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Publisher version:
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https://doi.org/10.1021/acsabm.9b00338
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Project ID:
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info:eu-repo/grantAgreement/MINECO//CTQ2014-58989-P/ES/BIONANORROBOTS QUIMICAMENTE PROGRAMADOS Y CONTROLADOS POR ENZIMAS/
info:eu-repo/grantAgreement/MINECO//CTQ2015-71936-REDT/ES/MODIFICACION QUIMICA DEL GRAFENO PARA NUEVAS PROPIEDADES Y APLICACIONES/
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-87954-P/ES/NANOMAQUINAS INTELIGENTES BASADAS EN NANOMATERIALES JANUS/
info:eu-repo/grantAgreement/MINECO//MAT2015-64139-C4-1-R/ES/NANOMATERIALES INTELIGENTES, SONDAS Y DISPOSITIVOS PARA EL DESARROLLO INTEGRADO DE NUEVAS HERRAMIENTAS APLICADAS AL CAMPO BIOMEDICO/
info:eu-repo/grantAgreement/GVA//PROMETEO%2F2018%2F024/ES/Sistemas avanzados de liberación controlada/
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Description:
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American Chemical Society
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Thanks:
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Financial support from the Spanish Ministry of Economy and Competitiveness (projects CTQ2014-58989-P, CTQ2015-71936-REDT, CTQ2017-87954-P, and MAT2015-64139-C4-1-R) and generalitat Valenciana (project PROMETEO/2018/024) ...[+]
Financial support from the Spanish Ministry of Economy and Competitiveness (projects CTQ2014-58989-P, CTQ2015-71936-REDT, CTQ2017-87954-P, and MAT2015-64139-C4-1-R) and generalitat Valenciana (project PROMETEO/2018/024) is gratefully acknowledged.
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Type:
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Artículo
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