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dc.contributor.author | Montesinos-Magraner, M. | es_ES |
dc.contributor.author | Vila, C. | es_ES |
dc.contributor.author | Blay, G. | es_ES |
dc.contributor.author | Fernández, I. | es_ES |
dc.contributor.author | Muñoz Roca, María Del Carmen | es_ES |
dc.contributor.author | Pedro, J.R. | es_ES |
dc.date.accessioned | 2020-04-17T12:48:24Z | |
dc.date.available | 2020-04-17T12:48:24Z | |
dc.date.issued | 2017 | es_ES |
dc.identifier.issn | 1523-7060 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/140846 | |
dc.description.abstract | [EN] A Cinchona-derived squaramide catalyzes the reaction between hydroxyindoles and isatins leading to enantioenriched indoles substituted in the carbocyclic ring. The reaction proceeds efficiently with differently substituted isatins, yielding the desired products with excellent regioselectivity, good yields, and high enantiocontroi. Moreover, every position of the carbocyclic ring of the indole can be functionalized by using the appropriate starting hydroxyindole. The OH group was removed smoothly upon hydrogenolysis of the corresponding triflate. | es_ES |
dc.description.sponsorship | Financial support from MINECO (Gobierno de Espana; CTQ2013-47494-P). M.M-M. thanks Universitat de Valencia for a predoctoral grant, and C.V. thanks MINECO for a JdC contract. Access to NMR and MS facilities from the SCSIE-UV. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.relation.ispartof | Organic Letters | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject.classification | FISICA APLICADA | es_ES |
dc.title | Hydroxy-Directed Enantioselective Hydroxyalkylation in the Carbocyclic Ring of Indoles | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1021/acs.orglett.7b00354 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//CTQ2013-47494-P/ES/NUEVOS RETOS EN EL DESARROLLO DE PROCESOS ENANTIOSELECTIVOS DE FORMACION DE ENLACES C-C MEDIANTE CATALISIS DUAL COOPERATIVA./ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada | es_ES |
dc.description.bibliographicCitation | Montesinos-Magraner, M.; Vila, C.; Blay, G.; Fernández, I.; Muñoz Roca, MDC.; Pedro, J. (2017). Hydroxy-Directed Enantioselective Hydroxyalkylation in the Carbocyclic Ring of Indoles. Organic Letters. 19(7):1546-1549. https://doi.org/10.1021/acs.orglett.7b00354 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1021/acs.orglett.7b00354 | es_ES |
dc.description.upvformatpinicio | 1546 | es_ES |
dc.description.upvformatpfin | 1549 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 19 | es_ES |
dc.description.issue | 7 | es_ES |
dc.relation.pasarela | S\351184 | es_ES |
dc.contributor.funder | Universitat de València | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |